@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS053 prodottidellaricerca:prodotto prodotto:ID33095 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA6038 pubblicazioni:autoreCNRDi prodotto:ID33095 . @prefix rdf: . prodotto:ID33095 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID33095 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID33095 rdfs:label "Use of Hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID33095 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID33095 skos:altLabel "
S. Fanali, G. D\u0092Orazio, M. G. Quaglia, A. Rocco (2004)
Use of Hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography
in Journal of chromatography (Print)
"^^rdf:HTML ; pubblicazioni:autori "S. Fanali, G. D\u0092Orazio, M. G. Quaglia, A. Rocco"^^xsd:string ; pubblicazioni:paginaInizio "247"^^xsd:string ; pubblicazioni:numeroVolume "1051"^^xsd:string . @prefix ns10: . prodotto:ID33095 pubblicazioni:rivista ns10:ID294073 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Use of Hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography"^^xsd:string ; prodottidellaricerca:abstract "Hepta-Tyr antibiotic modified silica stationary phase was used for the chiral resolution of d,l-loxiglumide, a new drug under investigation\nproposed for the treatment of gastrointestinal diseases. The chiral stationary phase was packed into fused silica capillaries of 75micron i.d. for a length of only 7 cm and used for both capillary electrochromatography (CEC) and nano-liquid chromatography (nano-LC) running the experiments with the same instrumentation; in order to increase the electroosmotic flow (EOF) the antibiotic stationary phase was mixed with amino-silica particles (3:1, w/w) generating a relatively high reversed EOF. The enantiomeric resolution of loxiglumide by CEC was strongly influenced by several experimental parameters such as applied electric field, mobile phase composition, capillary temperature, etc. Optimum experimental conditions were found applying 15 kV at 20 \u00E6C and eluting with acetonitrile\u0096sodium phosphate buffer at pH 6 (1:1, v/v). The same capillary was tested for nano-LC experiments. Good chiral separation of loxiglumide was achieved selecting the appropriate mobile phase considering the type and concentration of organic modifier. The nano-LC optimised method was therefore validated and applied to the analysis of a pharmaceutical formulation declared to contain only d-loxiglumide." ; prodottidellaricerca:prodottoDi istituto:CDS053 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA6038 . @prefix parolechiave: . prodotto:ID33095 parolechiave:insiemeDiParoleChiave . ns10:ID294073 pubblicazioni:rivistaDi prodotto:ID33095 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID33095 .