@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS053 prodottidellaricerca:prodotto prodotto:ID32960 . @prefix rdf: . prodotto:ID32960 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID32960 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID32960 rdfs:label "Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers (Articolo in rivista)"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID32960 pubblicazioni:anno "2002-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID32960 skos:altLabel "
Quaglia M.G., Donati E., Desideri N., Fanali S., D'Auria F.D., Tecca M. (2002)
Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers
in Chirality (N.Y., N.Y. Print)
"^^rdf:HTML ; pubblicazioni:autori "Quaglia M.G., Donati E., Desideri N., Fanali S., D'Auria F.D., Tecca M."^^xsd:string ; pubblicazioni:paginaInizio "449"^^xsd:string ; pubblicazioni:paginaFine "454"^^xsd:string ; pubblicazioni:numeroVolume "14"^^xsd:string . @prefix ns9: . prodotto:ID32960 pubblicazioni:rivista ns9:ID506387 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers"^^xsd:string ; prodottidellaricerca:abstract "Fenticonazole is a chiral antifungal agent, used in therapy as the racemic \nmixture. The investigation on the chirality fenticonazole is reported in \nthis study. Rac-fenticonazole was resolved by HPLC and by capillary \nelectrophoresis (CE). The chiral stationary phase (CSP) used in HPLC, was \nDaicel OD-H, a commercial phase, which allowed the separate collection of \nthe two enantiomers. The analysis time required from CE was about the half \nof that of HPLC enantioseparation time. The biological activity of the rac-\nmixture and each individual enantiomer was tested against Cryptococcus \nneoformans and two Aspergillus nidulans strains. the minimum inhibitory \nconcentration (MIC) evaluation showed that the eutomer was the enantiomer \nchromatographically more retained and had a longer migration time in the \nelectrophoretic enantiomer separation. The CD spectrum of the eutomer \nshowed a positive cotton effect." ; prodottidellaricerca:prodottoDi istituto:CDS053 . ns9:ID506387 pubblicazioni:rivistaDi prodotto:ID32960 .