@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS051 prodottidellaricerca:prodotto prodotto:ID31953 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA10141 pubblicazioni:autoreCNRDi prodotto:ID31953 . unitaDiPersonaleInterno:MATRICOLA1494 pubblicazioni:autoreCNRDi prodotto:ID31953 . @prefix modulo: . modulo:ID4156 prodottidellaricerca:prodotto prodotto:ID31953 . @prefix rdf: . prodotto:ID31953 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID31953 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID31953 rdfs:label "The Role of Hydroxyapatite as Solid Signal on Performance of PCL Porous Scaffolds for Bone Tissue Regeneration (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID31953 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID31953 skos:altLabel "
Guarino V.; Causa F.; Netti P.A.; Ciapetti G.; Pagani S.; Martini D.; Baldini N.; Ambrosio L.; (2008)
The Role of Hydroxyapatite as Solid Signal on Performance of PCL Porous Scaffolds for Bone Tissue Regeneration
in Tissue engineering. Part A (Online)
"^^rdf:HTML ; pubblicazioni:autori "Guarino V.; Causa F.; Netti P.A.; Ciapetti G.; Pagani S.; Martini D.; Baldini N.; Ambrosio L.;"^^xsd:string ; pubblicazioni:paginaInizio "548"^^xsd:string ; pubblicazioni:paginaFine "557"^^xsd:string ; pubblicazioni:numeroVolume "86"^^xsd:string . @prefix ns11: . prodotto:ID31953 pubblicazioni:rivista ns11:ID134653 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Composite and Biomedical Materials, National Research Council and CRIB, University of Naples \u0091\u0091Federico II\u0092\u0092\nPiazzale Tecchio 80, 80125 Naples, Italy\nDepartment of Experimental and Clinical Medicine, University of Magna Graecia, Germaneto, 88100 Catanzaro, Italy\nLaboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, via di Barbiano 1/10,\n40136 Bologna, Italy\nDepartment of Human Anatomy, University of Bologna, via Irnerio 48, 40126 Bologna, Italy"^^xsd:string ; pubblicazioni:titolo "The Role of Hydroxyapatite as Solid Signal on Performance of PCL Porous Scaffolds for Bone Tissue Regeneration"^^xsd:string ; prodottidellaricerca:abstract "Highly porous composites made up of biodegradable poly-e-caprolactone (PCL) and stoichiometric hydroxyapatite (HA) particles have been developed as substrate for bonetissue regeneration. The processing technique consists of phase inversion and particulate (salt crystals) leaching. Three different HA contents (13, 20 and 26 vol %) in PCL-based composite were considered in this study. Pore microstructure with fully interconnected network and pore sizes ranging around a few hundred of lm (macroporosity) was obtained as a result of salt particles removal by leaching process. Several microns (microporosity) porosity was also\ncreated through phase inversion of polymer solution. Total porosity up to 95% was achieved. Human marrow stromal cells (MSC) were seeded onto porous PCL-based composites for 1\u00965 weeks and cultured in osteogenic medium. MSC were able to adhere and grow on PCL-based substrates with a plateau at 3\u00964 weeks. However, the small effect of bioactive signals on the biological response evaluated in MSC cell culture suggests a prior role of topography on the biological response. Importantly, the presence of HA as a bioactive solid signal determines an increase of mechanical properties. On the overall, the results indicated that porous PCL-based\ncomposites are potential candidate for bone substitution with beneficial influence on structural characteristics by solid signal addition." ; prodottidellaricerca:prodottoDi modulo:ID4156 , istituto:CDS051 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA1494 , unitaDiPersonaleInterno:MATRICOLA10141 . @prefix parolechiave: . prodotto:ID31953 parolechiave:insiemeDiParoleChiave . ns11:ID134653 pubblicazioni:rivistaDi prodotto:ID31953 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID31953 .