@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA5636 pubblicazioni:autoreCNRDi prodotto:ID313316 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID313316 . @prefix rdf: . prodotto:ID313316 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID313316 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID313316 rdfs:label "Metformin selectively affects human glioblastoma tumor-initiating cell viability A role for metformin-induced inhibition of Akt (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID313316 pubblicazioni:anno "2013-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.4161/cc.23050"^^xsd:string . @prefix skos: . prodotto:ID313316 skos:altLabel "
Wuerth, Roberto; Pattarozzi, Alessandra; Gatti, Monica; Bajetto, Adriana; Corsaro, Alessandro; Parodi, Alessia; Sirito, Rodolfo; Massollo, Michela; Marini, Cecilia; Zona, Gianluigi; Fenoglio, Daniela; Sambuceti, Gianmario; Filaci, Gilberto; Daga, Antonio; Barbieri, Federica; Florio, Tullio (2013)
Metformin selectively affects human glioblastoma tumor-initiating cell viability A role for metformin-induced inhibition of Akt
in Cell cycle (Georget. Tex.); Landes Bioscience, Georgetown , TX (Stati Uniti d'America)
"^^rdf:HTML ; pubblicazioni:autori "Wuerth, Roberto; Pattarozzi, Alessandra; Gatti, Monica; Bajetto, Adriana; Corsaro, Alessandro; Parodi, Alessia; Sirito, Rodolfo; Massollo, Michela; Marini, Cecilia; Zona, Gianluigi; Fenoglio, Daniela; Sambuceti, Gianmario; Filaci, Gilberto; Daga, Antonio; Barbieri, Federica; Florio, Tullio"^^xsd:string ; pubblicazioni:paginaInizio "145"^^xsd:string ; pubblicazioni:paginaFine "156"^^xsd:string ; pubblicazioni:numeroVolume "12"^^xsd:string . @prefix ns10: . prodotto:ID313316 pubblicazioni:rivista ns10:ID65908 ; pubblicazioni:pagineTotali "12"^^xsd:string ; pubblicazioni:numeroFascicolo "1"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "University of Genoa; University of Genoa; University of Genoa; University of Genoa; Consiglio Nazionale delle Ricerche (CNR); University of Genoa; University of Genoa; University of Genoa"^^xsd:string ; pubblicazioni:titolo "Metformin selectively affects human glioblastoma tumor-initiating cell viability A role for metformin-induced inhibition of Akt"^^xsd:string ; prodottidellaricerca:abstract "Cancer stem cell theory postulates that a small population of tumor-initiating cells is responsible for the development, progression and recurrence of several malignancies, including glioblastoma. In this perspective, tumor-initiating cells represent the most relevant target to obtain effective cancer treatment. Metformin, a first-line drug for type II diabetes, was reported to possess anticancer properties affecting the survival of cancer stem cells in breast cancer models. We report that metformin treatment reduced the proliferation rate of tumor-initiating cell-enriched cultures isolated from four human glioblastomas. Metformin also impairs tumor-initiating cell spherogenesis, indicating a direct effect on self-renewal mechanisms. Interestingly, analyzing by FACS the antiproliferative effects of metformin on CD133-expressing subpopulation, a component of glioblastoma cancer stem cells, a higher reduction of proliferation was observed as compared with CD133-negative cells, suggesting a certain degree of cancer stem cell selectivity in its effects. In fact, glioblastoma cell differentiation strongly reduced sensitivity to metformin treatment. Metformin effects in tumor-initiating cell-enriched cultures were associated with a powerful inhibition of Akt-dependent cell survival pathway, while this pathway was not affected in differentiated cells. The specificity of metformin antiproliferative effects toward glioblastoma tumor-initiating cells was confirmed by the lack of significant inhibition of normal human stem cells (umbilical cord-derived mesenchymal stem cells) in vitro proliferation after metformin exposure. Altogether, these data clearly suggest that metformin exerts antiproliferative activity on glioblastoma cells, showing a higher specificity toward tumor-initiating cells, and that the inhibition of Akt pathway may represent a possible intracellular target of this effect."@en . @prefix ns11: . prodotto:ID313316 pubblicazioni:editore ns11:ID12353 ; prodottidellaricerca:prodottoDi istituto:CDS009 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA5636 . @prefix parolechiave: . prodotto:ID313316 parolechiave:insiemeDiParoleChiave . ns10:ID65908 pubblicazioni:rivistaDi prodotto:ID313316 . ns11:ID12353 pubblicazioni:editoreDi prodotto:ID313316 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID313316 .