@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID307072 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA1627 pubblicazioni:autoreCNRDi prodotto:ID307072 . @prefix modulo: . modulo:ID2652 prodottidellaricerca:prodotto prodotto:ID307072 . @prefix rdf: . prodotto:ID307072 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID307072 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID307072 rdfs:label "5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID307072 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.3389/fncel.2014.00250"^^xsd:string . @prefix skos: . prodotto:ID307072 skos:altLabel "
Ciranna, Lucia; Catania, Maria Vincenza (2014)
5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders
in Frontiers in cellular neuroscience
"^^rdf:HTML ; pubblicazioni:autori "Ciranna, Lucia; Catania, Maria Vincenza"^^xsd:string ; pubblicazioni:numeroVolume "8"^^xsd:string . @prefix ns11: . prodotto:ID307072 pubblicazioni:rivista ns11:ID118419 ; pubblicazioni:pagineTotali "17"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "University of Catania; Natl Res Council Italy CNR; IRCCS Oasi Maria SS"^^xsd:string ; pubblicazioni:titolo "5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders"^^xsd:string ; prodottidellaricerca:abstract "Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain development, synaptic transmission and plasticity, and therefore are involved in various brain functions such as learning and memory. A number of studies suggest that 5-HT7 receptors could be potential pharmacotherapeutic target for cognitive disorders. Several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (ASD), including abnormal activity of 5-HT transporter, altered blood and brain 5-HT levels, reduced 5-HT synthesis and altered expression of 5-HT receptors in the brain. A specific role for 5-HT7 receptors in ASD has not yet been demonstrated but some evidence implicates their possible involvement. We have recently shown that 5-HT7 receptor activation rescues hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome, a monogenic cause of autism. Several other studies have shown that 5-HT7 receptors modulate behavioral flexibility, exploratory behavior, mood disorders and epilepsy, which include core and co-morbid symptoms of ASD. These findings further suggest an involvement of 5-HT7 receptors in ASD. Here, we review the physiological roles of 5-HT7 receptors and their implications in Fragile X Syndrome and other ASD."@en ; prodottidellaricerca:prodottoDi istituto:CDS081 , modulo:ID2652 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA1627 . @prefix parolechiave: . prodotto:ID307072 parolechiave:insiemeDiParoleChiave . ns11:ID118419 pubblicazioni:rivistaDi prodotto:ID307072 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID307072 .