@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID25089 pubblicazioni:autoreCNRDi prodotto:ID302545 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID302545 . @prefix modulo: . modulo:ID9298 prodottidellaricerca:prodotto prodotto:ID302545 . @prefix rdf: . @prefix retescientifica: . prodotto:ID302545 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID302545 rdfs:label "Is overwork weakness relevant in Charcot-Marie-Tooth disease? (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID302545 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1136/jnnp-2014-307598"^^xsd:string . @prefix skos: . prodotto:ID302545 skos:altLabel "
Piscosquito, G.; Reilly, M. M.; Schenone, A.; Fabrizi, G. M.; Cavallaro, T.; Santoro, L.; Vita, G.; Quattrone, A.; Padua, L.; Gemignani, F.; Visioli, F.; Laura, M.; Calabrese, D.; Hughes, R. A. C.; Radice, D.; Solari, A.; Pareyson, D. (2014)
Is overwork weakness relevant in Charcot-Marie-Tooth disease?
in Journal of neurology, neurosurgery and psychiatry
"^^rdf:HTML ; pubblicazioni:autori "Piscosquito, G.; Reilly, M. M.; Schenone, A.; Fabrizi, G. M.; Cavallaro, T.; Santoro, L.; Vita, G.; Quattrone, A.; Padua, L.; Gemignani, F.; Visioli, F.; Laura, M.; Calabrese, D.; Hughes, R. A. C.; Radice, D.; Solari, A.; Pareyson, D."^^xsd:string ; pubblicazioni:paginaInizio "1354"^^xsd:string ; pubblicazioni:paginaFine "1358"^^xsd:string ; pubblicazioni:numeroVolume "85"^^xsd:string . @prefix ns11: . prodotto:ID302545 pubblicazioni:rivista ns11:ID387148 ; pubblicazioni:pagineTotali "5"^^xsd:string ; pubblicazioni:numeroFascicolo "12"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "1 IRCCS Foundation, C. Besta Neurological Institute, Milan, Italy.\n2 MRC Centre for Neuromuscular diseases, UCL Institute of Neurology, London, UK.\n3 Department of Neurology, Ophthalmology and Genetics, University of Genoa, Genoa, Italy.\n4 Department of Neurological, Neuropsychological, Morphological and Motor Sciences, University of Verona, Verona, Italy.\n5 Federico II University Department of Neurological Sciences, Naples, Italy.\n6 Department of Neurosciences, University of Messina, and Clinical Centre NEMO SUD, Fondazione Aurora Onlus, Messina, Italy.\n7 Neurology Clinic, Magna Graecia University, and Neuroimaging Research Unit, National Research Council, Catanzaro, Italy.\n8 Department of Neurosciences, Catholic University and Don Gnocchi Foundation, Rome, Italy.\n9 Department of Neurosciences, University of Parma, Parma, Italy.\n10 Department of Pharmacological Sciences, University School of Pharmacy, Milan, Italy IMDEA-Food, Madrid, Spain.\n11 Department of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy."^^xsd:string ; pubblicazioni:titolo "Is overwork weakness relevant in Charcot-Marie-Tooth disease?"^^xsd:string ; prodottidellaricerca:abstract "BACKGROUND:\nIn overwork weakness (OW), muscles are increasingly weakened by exercise, work or daily activities. Although it is a well-established phenomenon in several neuromuscular disorders, it is debated whether it occurs in Charcot-Marie-Tooth disease (CMT). Dominant limb muscles undergo a heavier overload than non-dominant and therefore if OW occurs we would expect them to become weaker. Four previous studies, comparing dominant and non-dominant hand strength in CMT series employing manual testing or myometry, gave contradictory results. Moreover, none of them examined the behaviour of lower limb muscles.\nMETHODS:\nWe tested the OW hypothesis in 271 CMT1A adult patients by comparing bilateral intrinsic hand and leg muscle strength with manual testing as well as manual dexterity.\nRESULTS:\nWe found no significant difference between sides for the strength of first dorsal interosseous, abductor pollicis brevis, anterior tibialis and triceps surae. Dominant side muscles did not become weaker than non-dominant with increasing age and disease severity (assessed with the CMT Neuropathy Score); in fact, the dominant triceps surae was slightly stronger than the non-dominant with increasing age and disease severity.\nDISCUSSION:\nOur data does not support the OW hypothesis and the consequent harmful effect of exercise in patients with CMT1A. Physical activity should be encouraged, and rehabilitation remains the most effective treatment for CMT patients.\nPublished by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions."@en ; prodottidellaricerca:prodottoDi istituto:CDS009 , modulo:ID9298 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID25089 . @prefix parolechiave: . prodotto:ID302545 parolechiave:insiemeDiParoleChiave . ns11:ID387148 pubblicazioni:rivistaDi prodotto:ID302545 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID302545 .