@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS045 prodottidellaricerca:prodotto prodotto:ID30203 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA16929 pubblicazioni:autoreCNRDi prodotto:ID30203 . @prefix modulo: . modulo:ID2507 prodottidellaricerca:prodotto prodotto:ID30203 . @prefix rdf: . @prefix retescientifica: . prodotto:ID30203 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID30203 rdfs:label "Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID30203 pubblicazioni:anno "2005-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1002/hep.20896"^^xsd:string . @prefix skos: . prodotto:ID30203 skos:altLabel "
Musso G.; Gambino R.; Durazzo M.; Biroli G.; Carello M.; Fag\u00E0 E.; Pacini G.; De Michieli F.; Cassader M.; Rabbione L.; Premoli A.; and Pagano G. (2005)
Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease
in Hepatology (Baltim. Md.); Wiley, New York (Stati Uniti d'America)
"^^rdf:HTML ; pubblicazioni:autori "Musso G.; Gambino R.; Durazzo M.; Biroli G.; Carello M.; Fag\u00E0 E.; Pacini G.; De Michieli F.; Cassader M.; Rabbione L.; Premoli A.; and Pagano G."^^xsd:string ; pubblicazioni:paginaInizio "1175"^^xsd:string ; pubblicazioni:paginaFine "1183"^^xsd:string ; pubblicazioni:url "http://onlinelibrary.wiley.com/doi/10.1002/hep.20896/pdf"^^xsd:string ; pubblicazioni:numeroVolume "42"^^xsd:string . @prefix ns11: . prodotto:ID30203 pubblicazioni:rivista ns11:ID426824 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12: Department of Internal Medicine, University of Turin, Turin, Italy\n7: Metabolic Unit, Institute of Biomedical Engineering (ISIB), National Research Council, Padova, Italy."^^xsd:string ; pubblicazioni:titolo "Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease"^^xsd:string ; prodottidellaricerca:abstract "Circulating levels of four adipokines (adiponectin, TNF-?, leptin, and resistin) and the\npostprandial lipid and adiponectin responses to an oral fat load were assessed in 25 nonobese, non-diabetic patients with biopsy-proven nonalcoholic steatohepatitis (NASH) and\ncorrelated with metabolic indices and liver histology. Circulating adiponectin was lower in\nNASH compared with controls (5,476 ? 344 vs. 11,548 ? 836 ng/mL; P ? .00001) and on\nmultiple regression analysis correlated negatively with liver steatosis, necroinflammation\n(OR ? 5.0; P ? .009), and fibrosis (OR ? 8.0; P ? .003).The magnitude of postprandial\nlipemia was significantly higher in NASH than in controls and was related to fasting adiponectin (? ? ?0.78; P ? .00003). Controls showed a significant increase in serum adiponectin in response to the fat load, whereas patients with NASH showed a slight decrease.\nPostprandial free fatty acids response correlated inversely with adiponectin response in both\ngroups and independently predicted the severity of liver steatosis in NASH (? ? 0.51; P ?\n.031). In conclusion, hypoadiponectinemia is present before overt diabetes and obesity\nappear and correlates with the severity of liver histology in NASH. Impaired postprandial\nlipid metabolism may be an additional mechanism linking hypoadiponectinemia and NASH\nand posing a higher cardiovascular risk to these subjects. The mechanism(s) underlying these\ndifferences are unknown, but the type of dietary fat seems to play a role. These findings may\nhave important pathogenetic and therapeutic implications in both liver and metabolic disease. (HEPATOLOGY 2005;42:1175-1183.)"@en . @prefix ns12: . prodotto:ID30203 pubblicazioni:editore ns12:ID592 ; prodottidellaricerca:prodottoDi modulo:ID2507 , istituto:CDS045 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA16929 . ns11:ID426824 pubblicazioni:rivistaDi prodotto:ID30203 . ns12:ID592 pubblicazioni:editoreDi prodotto:ID30203 .