@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS045 prodottidellaricerca:prodotto prodotto:ID30180 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA16929 pubblicazioni:autoreCNRDi prodotto:ID30180 . @prefix modulo: . modulo:ID2507 prodottidellaricerca:prodotto prodotto:ID30180 . @prefix rdf: . @prefix retescientifica: . prodotto:ID30180 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID30180 rdfs:label "Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID30180 pubblicazioni:anno "2005-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.2337/diacare.28.8.1936"^^xsd:string . @prefix skos: . prodotto:ID30180 skos:altLabel "
Ahr\u00E9n B.; Pacini G.; Foley J.; Schweizer A. (2005)
Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
in Diabetes care
"^^rdf:HTML ; pubblicazioni:autori "Ahr\u00E9n B.; Pacini G.; Foley J.; Schweizer A."^^xsd:string ; pubblicazioni:paginaInizio "1936"^^xsd:string ; pubblicazioni:paginaFine "1940"^^xsd:string ; pubblicazioni:url "http://care.diabetesjournals.org/content/28/8/1936.long"^^xsd:string ; pubblicazioni:numeroVolume "28"^^xsd:string . @prefix ns11: . prodotto:ID30180 pubblicazioni:rivista ns11:ID318181 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1: Department of Medicine, Lund University, Sweden/\n2: Metabolic Unit, Institute of Biomedical Engineering, Italian National Research Council, Padua, Italy/\n3: Novartis Pharmaceuticals, East Hanover, New Jersey/\n4 Novartis Pharma, Basel, Switzerland/"^^xsd:string ; pubblicazioni:titolo "Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year"^^xsd:string ; prodottidellaricerca:abstract "To examine the effects of dipeptidyl peptidase-IV (DPP-4) inhibition on\nmeal-related ?-cell function and insulin sensitivity over 52 weeks in type 2 diabetes.\nRESEARCH DESIGN AND METHODS -- In a 12-week core study, placebo (n ? 51) or\nvildagliptin (n ? 56; 50 mg OD) was added to metformin treatment (1.5-3.0 mg/day). A\n40-week extension followed in 71 patients. Meal tests were performed at 0, 12, 24, and 52 weeks;\nglucose, insulin, and C-peptide were evaluated.\nRESULTS -- In subjects completing 52 weeks with participation in all meal tests (n ? 57),\nHbA1c\n(A1C) decreased in the vildagliptin/metformin group (VM group, n ? 31) but increased\nin the placebo/metformin group (PM group, n ? 26; between-group difference ?1.0 ? 0.2%;\nP ? 0.001; baseline of all subjects combined 7.7 ? 0.1%). Also, fasting glucose decreased in the\nVM group but increased in the PM group (difference ?0.9 ? 0.3 mmol/l, P ? 0.016; baseline\n9.8 ? 0.3 mmol/l). Insulin secretion (postmeal suprabasal area under the 0- to 30-min C-peptide\ncurve divided by the 30-min increase in glucose) was increased in the VM group but was reduced\nin the PM group (difference ?0.011 ? 0.03 pmol/l 30 min/mmol/l, P ? 0.018; baseline 0.036 ?\n0.02). Insulin sensitivity during meal ingestion (oral glucose insulin sensitivity) increased in the\nVM group but was not altered in the PM group (difference ?27 ? 4 ml ? min\n?1\n? m\n?2\n, P ? 0.036;\nbaseline 246 ? 6). Insulin secretion related to insulin sensitivity (adaptation index) increased in\nthe VM group but decreased in the PM group (difference ?3.2 ? 1.0, P ? 0.040; baseline 9.1 ?\n0.5). The change in adaptation index correlated to the change in A1C (r ? ?0.39, P ? 0.004).\nCONCLUSIONS -- This study presents evidence that DPP-4 inhibition by vildagliptin when\nadded to metformin in type 2 diabetes over 52 weeks improves ?-cell function along with\nimproved postmeal insulin sensitivity"@en ; prodottidellaricerca:prodottoDi istituto:CDS045 , modulo:ID2507 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA16929 . ns11:ID318181 pubblicazioni:rivistaDi prodotto:ID30180 .