@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID298939 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA19184 pubblicazioni:autoreCNRDi prodotto:ID298939 . @prefix modulo: . modulo:ID8708 prodottidellaricerca:prodotto prodotto:ID298939 . @prefix rdf: . @prefix retescientifica: . prodotto:ID298939 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID298939 rdfs:label "Functional analysis and case-control study of -160C/A polymorphism in the E-cadherin gene promoter: Association with cancer risk (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID298939 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID298939 skos:altLabel "
Cattaneo F.; Venesio T.; Molatore S.; Russo A.; Fiocca R.; Frattini M.; Scovassi A.I.; Ottini L.; Bertario L.; Ranzani G.N. (2006)
Functional analysis and case-control study of -160C/A polymorphism in the E-cadherin gene promoter: Association with cancer risk
in Anticancer research
"^^rdf:HTML ; pubblicazioni:autori "Cattaneo F.; Venesio T.; Molatore S.; Russo A.; Fiocca R.; Frattini M.; Scovassi A.I.; Ottini L.; Bertario L.; Ranzani G.N."^^xsd:string ; pubblicazioni:paginaInizio "4627"^^xsd:string ; pubblicazioni:paginaFine "4632"^^xsd:string ; pubblicazioni:url "http://www.scopus.com/inward/record.url?eid=2-s2.0-33845953621&partnerID=q2rCbXpz"^^xsd:string ; pubblicazioni:numeroVolume "26"^^xsd:string . @prefix ns11: . prodotto:ID298939 pubblicazioni:rivista ns11:ID425482 ; pubblicazioni:numeroFascicolo "6"^^xsd:string ; skos:note "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy; Unit of Pathology, Institute for Cancer Research and Treatment, 10060 Candiolo-Torino, Italy; Epidemiology Unit, Local Health Authority, 20122 Milano, Italy; Department of Surgical and Morphological Sciences, University of Genova, 16132 Genova, Italy; National Cancer Institute, INT, 20133 Milano, Italy; Institute of Molecular Genetics, CNR, 27100 Pavia, Italy; Department of Experimental Medicine and Pathology, University La Sapienza, 00161 Roma, Italy; Department of Genetics and Microbiology, University of Pavia, Via Abbiategrasso 207, 27100 Pavia, Italy"^^xsd:string ; pubblicazioni:titolo "Functional analysis and case-control study of -160C/A polymorphism in the E-cadherin gene promoter: Association with cancer risk"^^xsd:string ; prodottidellaricerca:abstract "Background: A C->A polymorphism within the CDH1 (E-cadherin) promoter seems to be associated with a reduced efficiency of gene transcription in vitro. Due to the crucial role of E-cadherin in epithelia, tissue-specific effect of C->A change on CDH1 transcription was tested and a case-control study was performed on patients affected with epithelial tumors. Patients and Methods: The -178/+93 CDH1 region containing either C or A nucleotide was inserted upstream of the Luciferase reporter gene in the pGL-2 vector, and the construct activity was assessed by transient transfection assay in HeLa and HCT116 cells. Results: A significantly lower activity for pGL-2A was found compared to pGL-2C, both in HeLa (54% decrease) and in HCT116 (67% decrease) cells. Genotyping of 246 controls and 505 patients affected with breast, gastric, colorectal, cervical and endometrial cancers demonstrated an association between the A allele and an increased risk of colorectal, gastric and endometrial tumors (1.66-, 1.81- and 2.35-fold, respectively). Conclusion: Our data support the notion that the A allele may act as a low-penetrance cancer susceptibility gene."@en ; prodottidellaricerca:prodottoDi modulo:ID8708 , istituto:CDS040 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19184 . @prefix parolechiave: . prodotto:ID298939 parolechiave:insiemeDiParoleChiave . ns11:ID425482 pubblicazioni:rivistaDi prodotto:ID298939 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID298939 .