@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID25089 pubblicazioni:autoreCNRDi prodotto:ID294587 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID294587 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA10105 pubblicazioni:autoreCNRDi prodotto:ID294587 . @prefix modulo: . modulo:ID9298 prodottidellaricerca:prodotto prodotto:ID294587 . unitaDiPersonaleInterno:MATRICOLA14444 pubblicazioni:autoreCNRDi prodotto:ID294587 . @prefix rdf: . @prefix retescientifica: . prodotto:ID294587 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID294587 rdfs:label "Structural 'connectomic' alterations in the limbic system of multiple sclerosis patients with major depression (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID294587 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1177/ 1352458514558474"^^xsd:string . @prefix skos: . prodotto:ID294587 skos:altLabel "
Salvatore Nigro, Luca Passamonti, Roberta Riccelli, Nicola Toschi, Federico Rocca, Paola Valentino, Rita Nistic\u00F2, Francesco Fera and Aldo Quattrone (2014)
Structural 'connectomic' alterations in the limbic system of multiple sclerosis patients with major depression
in Multiple sclerosis (Online)
"^^rdf:HTML ; pubblicazioni:autori "Salvatore Nigro, Luca Passamonti, Roberta Riccelli, Nicola Toschi, Federico Rocca, Paola Valentino, Rita Nistic\u00F2, Francesco Fera and Aldo Quattrone"^^xsd:string ; pubblicazioni:altreInformazioni "Pubblicato on-line: 22 Dicembre 2014"^^xsd:string . @prefix ns12: . prodotto:ID294587 pubblicazioni:rivista ns12:ID222398 ; skos:note "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "1. Institute of Bioimaging and Molecular Physiology, National Research Council, Catanzaro, Italy.\n2. Institute of Bioimaging and Molecular Physiology, National Research Council, Catanzaro, Italy luca.passamonti@cnr.it.\n3. Department of Medical and Surgical Sciences, 'Magna Graecia' University, Catanzaro, Italy.\n4. Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy/AA Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA.\n5. Institute of Bioimaging and Molecular Physiology, National Research Council, Catanzaro, Italy/Department of Medical and Surgical Sciences, 'Magna Graecia' University, Catanzaro, Italy."^^xsd:string ; pubblicazioni:titolo "Structural 'connectomic' alterations in the limbic system of multiple sclerosis patients with major depression"^^xsd:string ; prodottidellaricerca:abstract "BACKGROUND:\nMajor depression (MD) is a common psychiatric disorder in multiple sclerosis (MS). Despite the negative impact of MD on the quality of life of MS patients, little is known about its underlying brain mechanisms.\nOBJECTIVE:\nWe studied the whole-brain connectivity patterns that were associated with MD in MS. Alterations were mainly expected within limbic circuits.\nMETHODS:\nDiffusion tensor imaging data were collected in 20 MS patients with MD, 22 non-depressed MS patients and 16 healthy controls. We used deterministic tractography and graph analysis to study the white-matter connectivity patterns that characterized MS patients with MD.\nRESULTS:\nWe found that MD in MS was associated with increased local path length in the right hippocampus and right amygdala. Further analyses revealed that these effects were driven by an increased shortest distance between both the right hippocampus and right amygdala and a series of regions including the dorsolateral and ventrolateral prefrontal cortex, orbitofrontal cortex, sensory-motor cortices and supplementary motor area.\nCONCLUSION:\nOur data provide strong support for neurobiological accounts positing that MD in MS is mediated by abnormal 'communications' within limbic circuits. We also found evidence that MD in MS may be linked with connectivity alterations at the limbic-motor interface, a group of regions that translates emotions into survival-oriented behaviors." ; prodottidellaricerca:prodottoDi modulo:ID9298 , istituto:CDS009 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA14444 , unitaDiPersonaleInterno:MATRICOLA10105 , unitaDiPersonaleEsterno:ID25089 , unitaDiPersonaleEsterno:ID24821 . @prefix parolechiave: . prodotto:ID294587 parolechiave:insiemeDiParoleChiave . ns12:ID222398 pubblicazioni:rivistaDi prodotto:ID294587 . unitaDiPersonaleEsterno:ID24821 pubblicazioni:autoreCNRDi prodotto:ID294587 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID294587 .