@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID287322 . @prefix modulo: . modulo:ID5927 prodottidellaricerca:prodotto prodotto:ID287322 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA14649 pubblicazioni:autoreCNRDi prodotto:ID287322 . @prefix rdf: . prodotto:ID287322 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID287322 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID287322 rdfs:label "Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID287322 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.jbior.2014.04.004"^^xsd:string . @prefix skos: . prodotto:ID287322 skos:altLabel "
Martelli AM, Lonetti A, Buontempo F, Ricci F, Tazzari PL, Evangelisti C, Bressanin D, Cappellini A, Orsini E, Chiarini F. (2014)
Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells
in Advances in Biological Regulation
"^^rdf:HTML ; pubblicazioni:autori "Martelli AM, Lonetti A, Buontempo F, Ricci F, Tazzari PL, Evangelisti C, Bressanin D, Cappellini A, Orsini E, Chiarini F."^^xsd:string ; pubblicazioni:paginaInizio "6"^^xsd:string ; pubblicazioni:paginaFine "21"^^xsd:string ; pubblicazioni:url "http://www.scopus.com/inward/record.url?eid=2-s2.0-84906729585&partnerID=q2rCbXpz"^^xsd:string ; pubblicazioni:numeroVolume "56"^^xsd:string . @prefix ns11: . prodotto:ID287322 pubblicazioni:rivista ns11:ID659395 ; skos:note "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "Department of Biomedical and Neuromotor Sciences, University of Bologna, via Irnerio 48, 40126 Bologna, Italy; Immunohematology and Transfusion Center, Policlinico S.Orsola-Malpighi, Bologna, Italy; Institute of Molecular Genetics, National Research Council, via di Barbiano 1/10, 40136 Bologna, Italy; Musculoskeletal Cell Biology Laboratory, IOR, via di Barbiano 1/10, 40136 Bologna, Italy; Department of Human, Social and Health Sciences, University of Cassino, 03043 Cassino, Italy"^^xsd:string ; pubblicazioni:titolo "Targeting Signaling Pathways in T-cell acute lymphoblastic leukemia initiating cells"^^xsd:string ; prodottidellaricerca:abstract "Leukemia initiating cells (LICs) represent a reservoir that is believed to drive relapse and resistance to chemotherapy in blood malignant disorders. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder of immature hematopoietic precursors committed to the T-cell lineage. T-ALL comprises about 15% of pediatric and 25% of adult ALL cases and is prone to early relapse. Although the prognosis of T-ALL has improved especially in children due to the use of new intensified treatment protocols, the outcome of relapsed T-ALL cases is still poor. Putative LICs have been identified also in T-ALL. LICs are mostly quiescent and for this reason highly resistant to chemotherapy. Therefore, they evade treatment and give rise to disease relapse. At present great interest surrounds the development of targeted therapies against signaling networks aberrantly activated in LICs and important for their survival and drug-resistance. Both the Notch1 pathway and the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) network are involved in T-ALL LIC survival and drug-resistance and could be targeted by small molecules. Thus, Notch1 and PI3K/Akt/mTOR inhibitors are currently being developed for clinical use either as single agents or in combination with conventional chemotherapy for T-ALL patient treatment. In this review, we summarize the existing knowledge of the relevance of Notch1 and PI3K/Akt/mTOR signaling in T-ALL LICs and we examine the rationale for targeting these key signal transduction networks by means of selective pharmacological inhibitors. \u00A9 2014 Elsevier Ltd."@en ; prodottidellaricerca:prodottoDi istituto:CDS040 , modulo:ID5927 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA14649 . @prefix parolechiave: . prodotto:ID287322 parolechiave:insiemeDiParoleChiave . ns11:ID659395 pubblicazioni:rivistaDi prodotto:ID287322 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID287322 .