@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS045 prodottidellaricerca:prodotto prodotto:ID285270 . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID285270 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA39052 pubblicazioni:autoreCNRDi prodotto:ID285270 . @prefix modulo: . modulo:ID2507 prodottidellaricerca:prodotto prodotto:ID285270 . @prefix rdf: . @prefix retescientifica: . prodotto:ID285270 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID285270 rdfs:label "Effects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophy (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID285270 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.2337/dc13-2040"^^xsd:string . @prefix skos: . prodotto:ID285270 skos:altLabel "
Muniyappa, R.; Brown, R. J.; Mari, A.; Joseph, J.; Warren, M. A.; Cochran, E. K.; Skarulis, M. C.; Gorden, P. (2014)
Effects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophy
in Diabetes care
"^^rdf:HTML ; pubblicazioni:autori "Muniyappa, R.; Brown, R. J.; Mari, A.; Joseph, J.; Warren, M. A.; Cochran, E. K.; Skarulis, M. C.; Gorden, P."^^xsd:string ; pubblicazioni:paginaInizio "1101"^^xsd:string ; pubblicazioni:paginaFine "1107"^^xsd:string ; pubblicazioni:url "http://www.ncbi.nlm.nih.gov/pubmed/24496806"^^xsd:string ; pubblicazioni:numeroVolume "37"^^xsd:string . @prefix ns11: . prodotto:ID285270 pubblicazioni:rivista ns11:ID318181 ; pubblicazioni:pagineTotali "7"^^xsd:string ; pubblicazioni:numeroFascicolo "4"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "1-2, 4-8: Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, \n3: Institute of Biomedical Engineering, National Research Council, Padova, Italy"^^xsd:string ; pubblicazioni:titolo "Effects of leptin replacement therapy on pancreatic beta-cell function in patients with lipodystrophy"^^xsd:string ; prodottidellaricerca:abstract "OBJECTIVE: Leptin administration is known to directly modulate pancreatic ?-cell function in leptin-deficient rodent models. However, human studies examining the effects of leptin administration on ?-cell function are lacking. In this study, we examined the effects (16-20 weeks) of leptin replacement on ?-cell function in patients with lipodystrophy. RESEARCH DESIGN AND METHODS: In a prospective, open-label, currently ongoing study, we studied the effects of leptin replacement on ?-cell function in 13 patients with congenital or acquired lipodystrophy. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution from plasma glucose and C-peptide levels measured during oral glucose tolerance tests (OGTTs) performed at baseline and after 16-20 weeks of leptin replacement. ?-Cell glucose sensitivity and rate sensitivity were assessed by mathematical modeling of OGTT. RESULTS: There was a significant decrease in triglycerides, free fatty acids, and glycosylated hemoglobin levels (A1C) after leptin therapy. Patients with lipodystrophy have high fasting and glucose-stimulated ISR. However, leptin therapy had no significant effect on fasting ISR, total insulin secretion during OGTT, ?-cell glucose sensitivity, rate sensitivity, or insulin clearance. CONCLUSIONS: In contrast to the suppressive effects of leptin on ?-cell function in rodents, 16-20-week treatment with leptin in lipodystrophy patients did not significantly affect insulin secretion or ?-cell function in leptin-deficient individuals with lipodystrophy. \u00A9 2014 by the American Diabetes Association."@en ; prodottidellaricerca:prodottoDi istituto:CDS045 , istituto:CDS061 , modulo:ID2507 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA39052 . ns11:ID318181 pubblicazioni:rivistaDi prodotto:ID285270 .