@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS045 prodottidellaricerca:prodotto prodotto:ID285265 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA16929 pubblicazioni:autoreCNRDi prodotto:ID285265 . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID285265 . @prefix modulo: . modulo:ID2507 prodottidellaricerca:prodotto prodotto:ID285265 . @prefix rdf: . @prefix retescientifica: . prodotto:ID285265 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID285265 rdfs:label "Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID285265 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1007/s00125-014-3328-3"^^xsd:string . @prefix skos: . prodotto:ID285265 skos:altLabel "
Kahl, S.; Nowotny, Bettina; P. S.; Nowotny, P. J.; Strassburger, K.; Herder, C.; Pacini, G.; Roden, M. (2014)
Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial
in Diabetologia (Berl.)
"^^rdf:HTML ; pubblicazioni:autori "Kahl, S.; Nowotny, Bettina; P. S.; Nowotny, P. J.; Strassburger, K.; Herder, C.; Pacini, G.; Roden, M."^^xsd:string ; pubblicazioni:paginaInizio "2094"^^xsd:string ; pubblicazioni:paginaFine "2102"^^xsd:string ; pubblicazioni:url "http://www.ncbi.nlm.nih.gov/pubmed/25047649"^^xsd:string ; pubblicazioni:numeroVolume "57"^^xsd:string . @prefix ns11: . prodotto:ID285265 pubblicazioni:rivista ns11:ID393682 ; pubblicazioni:pagineTotali "9"^^xsd:string ; pubblicazioni:numeroFascicolo "10"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; German Ctr Diabet Res; Heinrich Heine University Dusseldorf; Consiglio Nazionale delle Ricerche (CNR)"^^xsd:string ; pubblicazioni:titolo "Estimates of insulin sensitivity from the intravenous-glucose-modified-clamp test depend on suppression of lipolysis in type 2 diabetes: a randomised controlled trial"^^xsd:string ; prodottidellaricerca:abstract "Aims/hypothesis The combined IVGTT-hyperinsulinaemic-\neuglycaemic clamp (Botnia clamp) allows the assessment of\ninsulin secretion and sensitivity in one experiment. It remains\nunclear whether this clamp yields results comparable with\nthose of the standard hyperinsulinaemic-euglycaemic clamp\n(SHEC) in diabetes patients. We hypothesised that the IVGTT\ninduces responses affecting insulin sensitivity assessment.\nMethods Of 22 randomised diet- or metformin-treated patients\nwith well-controlled type 2 diabetes, 19 randomly\nunderwent a Botnia clamp and an SHEC, spaced by 2 weeks,\nin one clinical research centre in a crossover study. The main\noutcomes were whole-body and hepatic insulin sensitivity as\nmeasured by the clamp and [6,6-2\nH2]glucose. Substrate\nutilisation was assessed from indirect calorimetry and beta\ncell function from insulin dynamics during IVGTT.\nResults The values of whole-body insulin sensitivity obtained\nfrom Botnia clamp and SHEC were correlated (r=0.87,\np<0.001), but also revealed intra-individual variations.\nHepatic insulin sensitivity did not differ between experiments\nduring the clamp, but differed after IVGTT. The contribution of\nglucose oxidation to glucose disposal increased by 2.2\u00B10.3 and\n1.2\u00B10.4 mg kg fat-free mass (FFM)-1 min-1 (Botnia and SHEC,\np<0.05), whereas lipid oxidation decreased by 0.8\u00B10.1 and\n0.4\u00B10.1 mg kg FFM-1 min-1 (p<0.05) from baseline. Differences\nin NEFA (r=-0.60, p<0.01), but not C-peptide (r=-0.16,\np=0.52) or hepatic insulin sensitivity between IVGTT and\nplacebo before the clamps correlated with individual variations\nof insulin sensitivity.\nConclusions/interpretation The Botnia clamp provides similar\nestimates of insulin sensitivity as SHEC in patients with\ntype 2 diabetes, but changes in NEFA during IVGTT may\naffect insulin sensitivity and thereby the discrimination between\ninsulin-sensitive and insulin-resistant individuals.\nTrial registration: ClinicalTrials.gov NCT01397279\nFunding: The study was funded by the Ministry of Science\nand Research of the State of North Rhine-Westphalia and the\nGerman Federal Ministry of Health, and supported in part by\ngrants from the Federal Ministry for Research to the Centers for\nDiabetes Research, Helmholtz Alliance Imaging and Curing\nEnvironmental Metabolic Diseases and the Schmutzler-Stiftung." ; prodottidellaricerca:prodottoDi istituto:CDS061 , modulo:ID2507 , istituto:CDS045 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA16929 . @prefix parolechiave: . prodotto:ID285265 parolechiave:insiemeDiParoleChiave . ns11:ID393682 pubblicazioni:rivistaDi prodotto:ID285265 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID285265 .