@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID284291 . @prefix modulo: . modulo:ID7742 prodottidellaricerca:prodotto prodotto:ID284291 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA14867 pubblicazioni:autoreCNRDi prodotto:ID284291 . unitaDiPersonaleInterno:MATRICOLA14590 pubblicazioni:autoreCNRDi prodotto:ID284291 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID16302 pubblicazioni:autoreCNRDi prodotto:ID284291 . @prefix rdf: . prodotto:ID284291 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID284291 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID284291 rdfs:label "Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID284291 pubblicazioni:anno "2014-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1096/fj.14-252825"^^xsd:string . @prefix skos: . prodotto:ID284291 skos:altLabel "
Michele Salanova,*,1,2 Cecilia Gelfi,?,\u00A7,,1,2 Manuela Moriggi,? Michele Vasso,\u00A7,\u00B6 Agnese Vigan\u00F2,? Luigi Minafra,\u00B6 Gaetano Bonifacio,# Gudrun Schiffl,* Martina Gutsmann,* Dieter Felsenberg,+ Paolo Cerretelli,\u00A7 and Dieter Blottner* (2014)
Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis.
in The FASEB journal
"^^rdf:HTML ; pubblicazioni:autori "Michele Salanova,*,1,2 Cecilia Gelfi,?,\u00A7,,1,2 Manuela Moriggi,? Michele Vasso,\u00A7,\u00B6 Agnese Vigan\u00F2,? Luigi Minafra,\u00B6 Gaetano Bonifacio,# Gudrun Schiffl,* Martina Gutsmann,* Dieter Felsenberg,+ Paolo Cerretelli,\u00A7 and Dieter Blottner*"^^xsd:string ; pubblicazioni:paginaInizio "4748"^^xsd:string ; pubblicazioni:paginaFine "4763"^^xsd:string ; pubblicazioni:numeroVolume "28"^^xsd:string . @prefix ns12: . prodotto:ID284291 pubblicazioni:rivista ns12:ID486297 ; pubblicazioni:numeroFascicolo "11"^^xsd:string ; skos:note "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "*Center of Space Medicine Berlin, Neuromuscular Group, Institute of Anatomy, and + Center for Muscle and Bone Research (ZMK), Charit\u00E9 Universit\u00E4tsmedizin Berlin, Berlin, Germany; ? Department of\nBiomedical Sciences for Health, University of Milan, Milan, Italy; \u00A7 Consiglio Nazionale delle Ricerche (CNR), Institute of Bioimaging and Molecular Physiology, Segrate, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Donato, San Donato Milanese, Italy; \u00B6 Institute of Bioimaging and Molecular Physiology, CNR-Laboratorio di Tecnologie Oncologiche (LATO), Cefal\u00F9,\nItaly; and # Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland"^^xsd:string ; pubblicazioni:titolo "Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis."^^xsd:string ; prodottidellaricerca:abstract "In the present bed rest (BR) study, 23 volunteers were randomized into 3 subgroups: 60 d BR control (Ctr); BR with resistive exercise (RE; lower-limb load); and resistive vibration exercise (RVE; RE with superimposed vibration). The aim was to analyze by confocal and electron microscopy the effects of vibration on myofibril and filament integrity in soleus (Sol) and vastus lateralis (VL) muscle; differential proteomics of contractile, cytoskeletal, and costameric proteins (TN-C, ROCK1, and FAK); and expression of PGC1? and atrophy-related master genes MuRF1 and MuRF2. RVE (but not RE) preserved myofiber size and phenotype in Sol and VL by overexpressing MYBPC1 (42%, P<=0.01), WDR1 (39%, P<=0.01), sarcosin (84%, P<=0.01), and CKM (20%, P<=0.01) and prevented myofibrillar ultrastructural damage as detectable by MuRF1 expression. In Sol, cytoskeletal and contractile proteins were normalized by RVE, and TN-C increased (59%, P<=0.01); the latter also with RE (108%, P<=0.01). In VL, the outcomes of both RVE (acting on sarcosin and desmin) and RE (by way of troponinT-slow and MYL2) were similar. RVE appears to be a highly efficient countermeasure protocol against muscle atrophy and ultrastructural and molecular dysregulation induced by chronic disuse.-Salanova, M., Gelfi, C., Moriggi, M., Vasso, M., Vigan\u00F2, A., Minafra, L., Bonifacio, G., Schiffl, G., Gutsmann, M., Felsenberg, D., Cerretelli, P., Blottner, D. Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis."@en ; prodottidellaricerca:prodottoDi modulo:ID7742 , istituto:CDS009 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA14867 , unitaDiPersonaleInterno:MATRICOLA14590 , unitaDiPersonaleEsterno:ID16302 . @prefix parolechiave: . prodotto:ID284291 parolechiave:insiemeDiParoleChiave . ns12:ID486297 pubblicazioni:rivistaDi prodotto:ID284291 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID284291 .