@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID27827 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID8266 pubblicazioni:autoreCNRDi prodotto:ID27827 . @prefix modulo: . modulo:ID5927 prodottidellaricerca:prodotto prodotto:ID27827 . modulo:ID5952 prodottidellaricerca:prodotto prodotto:ID27827 . @prefix rdf: . prodotto:ID27827 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID27827 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID27827 rdfs:label "Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID27827 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID27827 skos:altLabel "
Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, B\u00E4secke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA. (2011)
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
in Leukemia
"^^rdf:HTML ; pubblicazioni:autori "Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, B\u00E4secke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA."^^xsd:string ; pubblicazioni:paginaInizio "1080"^^xsd:string ; pubblicazioni:paginaFine "1094"^^xsd:string ; pubblicazioni:numeroVolume "25"^^xsd:string . @prefix ns11: . prodotto:ID27827 pubblicazioni:rivista ns11:ID485716 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC, USA;\nDepartment of Physics, East Carolina University, Greenville, NC, USA; \nDepartment of Medicine, University of Gottingen,Go ttingen, Germany; \nDepartment of Biomedical Sciences, University of Catania, Catania, Italy;\nDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA;\nDipartimento di Scienze Anatomiche Umane e Fisiopatologia dell\u0092Apparato Locomotore, Universita` di Bologna, Bologna, Italy \nIGM-CNR, Sezione di Bologna, C/o IOR, Bologna, Italy\n"^^xsd:string ; pubblicazioni:titolo "Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy."^^xsd:string ; prodottidellaricerca:abstract "The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated signaling through the Ras/Raf/MEK/ERK pathway is often the result of genetic alterations in critical components in this pathway as well as mutations at upstream growth factor receptors. Unrestricted leukemia proliferation and decreased sensitivity to apoptotic-inducing agents and chemoresistance are typically associated with activation of pro-survival pathways. Mutations in this pathway and upstream signaling molecules can alter sensitivity to small molecule inhibitors targeting components of this cascade as well as to inhibitors targeting other key pathways (for example, phosphatidylinositol 3 kinase (PI3K)/phosphatase and tensin homologue deleted on chromosome 10 (PTEN)/Akt/mammalian target of rapamycin (mTOR)) activated in leukemia. Similarly, PI3K mutations can result in resistance to inhibitors targeting the Ras/Raf/MEK/ERK pathway, indicating important interaction points between the pathways (cross-talk). Furthermore, the Ras/Raf/MEK/ERK pathway can be activated by chemotherapeutic drugs commonly used in leukemia therapy. This review discusses the mechanisms by which abnormal expression of the Ras/Raf/MEK/ERK pathway can contribute to drug resistance as well as resistance to targeted leukemia therapy. Controlling the expression of this pathway could improve leukemia therapy and ameliorate human health.\n\n" ; prodottidellaricerca:prodottoDi istituto:CDS040 , modulo:ID5927 , modulo:ID5952 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID8266 . @prefix parolechiave: . prodotto:ID27827 parolechiave:insiemeDiParoleChiave . ns11:ID485716 pubblicazioni:rivistaDi prodotto:ID27827 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID27827 .