@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID27771 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA13676 pubblicazioni:autoreCNRDi prodotto:ID27771 . @prefix modulo: . modulo:ID5952 prodottidellaricerca:prodotto prodotto:ID27771 . @prefix rdf: . prodotto:ID27771 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID27771 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID27771 rdfs:label "Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID27771 pubblicazioni:anno "2010-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID27771 skos:altLabel "
Gobbi G, Masselli E, Micheloni C, Nouvenne A, Russo D, Santi P, Matteucci A, Cocco L, Vitale M, Mirandola P. (2010)
Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells.
in International journal of oncology
"^^rdf:HTML ; pubblicazioni:autori "Gobbi G, Masselli E, Micheloni C, Nouvenne A, Russo D, Santi P, Matteucci A, Cocco L, Vitale M, Mirandola P."^^xsd:string ; pubblicazioni:paginaInizio "719"^^xsd:string ; pubblicazioni:paginaFine "729"^^xsd:string ; pubblicazioni:numeroVolume "37"^^xsd:string . @prefix ns11: . prodotto:ID27771 pubblicazioni:rivista ns11:ID252755 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Human Anatomy, Pharmacology and Forensic Medicine, Human Anatomy Section, University of Parma\nCenter for Morphology and Body Composition (CMBC), University of Parma; \nDepartment of Clinical Sciences, University of Parma, Ospedale Maggiore, Via Gramsci 14, 43126 Parma;\nStem Cell Transplantation Unit, Department of Haematology, University of Brescia, Piazzale Spedali Civili 1, Brescia; Cellular Signalling Laboratory, Department of Anatomical Sciences, University of Bologna, Via Irnerio 48; \nIGM-CNR, Bologna Unit c/o I.O.R., Bologna, Italy"^^xsd:string ; pubblicazioni:titolo "Hypoxia-induced down-modulation of PKCepsilon promotes trail-mediated apoptosis of tumor cells."^^xsd:string ; prodottidellaricerca:abstract "Tumor oxygen status is considered as a prognostic marker that impacts on malignant progression and outcome of tumor therapy. TNF-related apoptosis inducing ligand (TRAIL) plays a key role in cancer immunity, with potential applications in cancer therapy. Protein kinase C (PKC)epsilon, a transforming oncogene, has a role in the protection of cardiomyocytes and neurons from hypoxia-induced damage while, it can also modulate the susceptibility of tumor cells to TRAIL-induced cell death. Here we demonstrate that hypoxia induces a tumor cell phenotype highly sensitive to the cytotoxic effects of TRAIL. Based on the observation that: i) PKCepsilon expression levels are impaired during hypoxia, ii) the overexpression of PKCepsilon, but not of a kinase-inactive PKCepsilon mutant, is able to revert the hypoxia-induced sensitivity to TRAIL, iii) the down-modulation of PKCepsilon levels by RNA interference, on the contrary, induces the highly TRAIL-sensitive phenotype, iv) the inhibition of hypoxia-inducible transcription factor-1alpha (HIF-1alpha) by specific siRNA blocks both the hypoxia-induced down-modulation of PKCepsilon and the induction of the highly TRAIL-sensitive phenotype; we conclude that the HIF-1alpha upregulation during hypoxia is associated to PKCepsilon down-modulation that likely represents the key molecular event promoting the apoptogenic effects of TRAIL in hypoxic tumor cells." ; prodottidellaricerca:prodottoDi modulo:ID5952 , istituto:CDS040 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA13676 . @prefix parolechiave: . prodotto:ID27771 parolechiave:insiemeDiParoleChiave . ns11:ID252755 pubblicazioni:rivistaDi prodotto:ID27771 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID27771 .