@prefix rdf: . @prefix prodotto: . prodotto:ID27647 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID27647 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID27647 rdfs:label "Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells. (Articolo in rivista)"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID27647 pubblicazioni:anno "2009-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID27647 skos:altLabel "
Cataldi A, Di Giacomo V, Rapino M, Zara S, Rana RA. (2009)
Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells.
"^^rdf:HTML ; pubblicazioni:autori "Cataldi A, Di Giacomo V, Rapino M, Zara S, Rana RA."^^xsd:string ; pubblicazioni:paginaInizio "202"^^xsd:string ; pubblicazioni:paginaFine "212"^^xsd:string ; pubblicazioni:numeroVolume "217"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Dipartimento di Biomorfologia, Universit\u00E0 G. d\u0092Annunzio, Chieti-Pescara, Chieti, Italy; Cattedra di Anatomia Umana, Facolt\u00E0 di Farmacia, Universit\u00E0 G. d\u0092Annunzio, Chieti-Pescara, Chieti, Italy; Istituto di Genetica Molecolare del CNR, Unit\u00E0 di Chieti, Chieti, Italy."^^xsd:string ; pubblicazioni:titolo "Ionizing radiation induces apoptotic signal through protein kinase Cdelta (delta) and survival signal through Akt and cyclic-nucleotide response element-binding protein (CREB) in Jurkat T cells."^^xsd:string . @prefix prodottidellaricerca: . prodotto:ID27647 prodottidellaricerca:abstract "Although ionizing radiation induces a loss of proliferative capacity as well as cell death by apoptosis and necrosis, cells can oppose the damaging effects by activating survival signal pathways. Here we report the effect of 1.5- and 6-Gy doses of ionizing radiation on apoptotic protein kinase Cdelta (PKCdelta) and survival cyclic-nucleotide response element-binding protein (CREB) signal in Jurkat T cells. Cell cycle analysis, performed by flow cytometry, showed a significant G2M arrest 24 h after exposure to 6 Gy. This arrest was accompanied by dead cells, which increased in number up to 7 days, when cell viability was further reduced. The response was apparently promoted by caspase-3-mediated PKCdelta activation, and thus apoptosis. Moreover, the presence of viable cells up to 7 days in samples exposed to 6 Gy is explained by Akt activation, which may influence the nuclear transcription factor CREB, leading to resistance to ionizing radiation. Thus, the knowledge of apoptotic and survival pathways activated in tumor cells may help in establishing specific therapies by combining selective inhibitors or stimulators of key signaling proteins with conventional chemotherapy, hormone therapy, and radiotherapy." . @prefix modulo: . prodotto:ID27647 prodottidellaricerca:prodottoDi modulo:ID5952 . @prefix istituto: . prodotto:ID27647 prodottidellaricerca:prodottoDi istituto:CDS040 . @prefix unitaDiPersonaleInterno: . prodotto:ID27647 pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA745 . unitaDiPersonaleInterno:MATRICOLA745 pubblicazioni:autoreCNRDi prodotto:ID27647 . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID27647 . modulo:ID5952 prodottidellaricerca:prodotto prodotto:ID27647 .