@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID27601 . @prefix modulo: . modulo:ID6455 prodottidellaricerca:prodotto prodotto:ID27601 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID10697 pubblicazioni:autoreCNRDi prodotto:ID27601 . @prefix rdf: . @prefix retescientifica: . prodotto:ID27601 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID27601 rdfs:label "Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID27601 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID27601 skos:altLabel "
Carletti B (a), Williams IM (a), Leto K (a), Nakajima K (c, d), Magrassi L (b), Rossi F (a). (2008)
Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture.
in Developmental biology (Print)
"^^rdf:HTML ; pubblicazioni:autori "Carletti B (a), Williams IM (a), Leto K (a), Nakajima K (c, d), Magrassi L (b), Rossi F (a)."^^xsd:string ; pubblicazioni:paginaInizio "147"^^xsd:string ; pubblicazioni:paginaFine "160"^^xsd:string ; pubblicazioni:numeroVolume "317"^^xsd:string . @prefix ns11: . prodotto:ID27601 pubblicazioni:rivista ns11:ID293514 ; pubblicazioni:pagineTotali "13"^^xsd:string ; pubblicazioni:numeroFascicolo "1"^^xsd:string ; skos:note "PubMed"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "a Department of Neuroscience and \\\"Rita Levi Montalcini Centre for Brain Repair\\\", National Institute of Neuroscience, University of Turin, Italy\nb Neurosurgery, Department of Surgery, IRCCS Policlinico S. Matteo, University of Pavia, Italy and IGM CNR\nc Department of Anatomy, Keio University School of Medicine, Tokyo, Japan\nd Department of Molecular Neurobiology, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan"^^xsd:string ; pubblicazioni:titolo "Time constraints and positional cues in the developing cerebellum regulate Purkinje cell placement in the cortical architecture."^^xsd:string ; prodottidellaricerca:abstract "To elucidate the mechanisms that regulate neuronal placement and integration in the cerebellar circuitry, we assessed the fate of Purkinje cells transplanted to embryonic, juvenile and adult hosts, asking how architectural changes of the developing cortex influence their anatomical incorporation. Donor Purkinje cells navigate through the host parenchyma either along their natural migratory pathway or following unusual routes. In the latter case, donor neurons fail to orientate correctly and to establish the cortico-nuclear projection. Purkinje cells that follow the physiological route achieve the typical orientation and connectivity, but end displaced in the molecular layer if their arrival in the recipient cortex is delayed. Navigation routes and final settling of donor neurons vary with host age, depending on the ontogenetic construction of cortical layering, and particularly on the maturation of granule cells. The migratory behavior and homing of transplanted Purkinje cells is modified after external granular layer ablation, or neutralization of reelin signaling produced by granule cells. Therefore, although the cerebellar milieu remains receptive for Purkinje cells even after the end of development, correct placement of donor neurons depends on the timing of their migration, related to cerebellar developmental dynamics and granule cell layering."@en ; prodottidellaricerca:prodottoDi istituto:CDS040 , modulo:ID6455 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID10697 . ns11:ID293514 pubblicazioni:rivistaDi prodotto:ID27601 .