@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID27331 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID11 pubblicazioni:autoreCNRDi prodotto:ID27331 . @prefix modulo: . modulo:ID2501 prodottidellaricerca:prodotto prodotto:ID27331 . @prefix rdf: . prodotto:ID27331 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID27331 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID27331 rdfs:label "In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID27331 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID27331 skos:altLabel "
Inghilleri S, Morbini P, Oggionni T, Barni S, Fenoglio C. (2006)
In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis.
in Histochemistry and cell biology
"^^rdf:HTML ; pubblicazioni:autori "Inghilleri S, Morbini P, Oggionni T, Barni S, Fenoglio C."^^xsd:string ; pubblicazioni:paginaInizio "661"^^xsd:string ; pubblicazioni:paginaFine "669"^^xsd:string ; pubblicazioni:numeroVolume "125"^^xsd:string . @prefix ns11: . prodotto:ID27331 pubblicazioni:rivista ns11:ID211729 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "I.F. 2005: 2.239"^^xsd:string ; pubblicazioni:titolo "In situ assessment of oxidant and nitrogenic stress in bleomycin pulmonary fibrosis."^^xsd:string ; prodottidellaricerca:abstract "Reactive oxygen species (ROS) and nitric oxide (NO) have a role in the development of pulmonary fibrosis after bleomycin administration. The ROS production induces an antioxidant response, involving superoxide dismutases (SODs), catalase, and glutathione peroxidases. We compared in situ oxidative burden and antioxidant enzyme activity in bleomycin-injured rat lungs and normal controls. ROS expression and catalase, glucose-6-phosphate-dehydrogenase (G6PHD), and NOS/NADPH-diaphorase activity were investigated by using histochemical reactions. Nitric oxide synthase (e-NOS and i-NOS) and SOD (MnSOD, Cu/ZnSOD, ECSOD) expression was investigated immunohistochemically. After treatment ROS production was enhanced in both phagocytes and in type II alveolar epithelial cells. Mn, Cu/Zn, and ECSOD were overexpressed in parenchymal cells, whereas interstitium expressed ECSOD. Catalase and G6PHD activity was moderately increased in parenchymal and inflammatory cells. NOS/NADPH-d activity and i-NOS expression increased in alveolar and bronchiolar epithelia and in inflammatory cells. It can be suggested that the concomitant activation of antioxidant enzymes is not adequate to scavenge the oxidant burden induced by bleomycin lung damage. Inflammatory cells and also epithelial cells are responsible of ROS and NO production. This oxidative and nitrosative stress may be a substantial trigger in TGF-beta1 overexpression by activated type II pneumocytes, leading to fibrotic lesions." ; prodottidellaricerca:prodottoDi istituto:CDS040 , modulo:ID2501 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID11 . @prefix parolechiave: . prodotto:ID27331 parolechiave:insiemeDiParoleChiave . ns11:ID211729 pubblicazioni:rivistaDi prodotto:ID27331 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID27331 .