@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8201 pubblicazioni:autoreCNRDi prodotto:ID26354 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS038 prodottidellaricerca:prodotto prodotto:ID26354 . @prefix modulo: . modulo:ID2534 prodottidellaricerca:prodotto prodotto:ID26354 . @prefix rdf: . @prefix retescientifica: . prodotto:ID26354 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID26354 rdfs:label "Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID26354 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID26354 skos:altLabel "
Hermanowski J; Bouzigon E; Forabosco P; Ng MY; Fisher SA; Lewis CM (2007)
Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method.
in European journal of human genetics
"^^rdf:HTML ; pubblicazioni:autori "Hermanowski J; Bouzigon E; Forabosco P; Ng MY; Fisher SA; Lewis CM"^^xsd:string ; pubblicazioni:paginaInizio "703"^^xsd:string ; pubblicazioni:paginaFine "710"^^xsd:string ; pubblicazioni:numeroVolume "15"^^xsd:string . @prefix ns11: . prodotto:ID26354 pubblicazioni:rivista ns11:ID239010 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Medical and Molecular Genetics, King's College London School of Medicine at Guy's, King's College and St Thomas' Hospitals, London, UK\nINSERM, U794, Evry, France\nIstituto di Genetica delle Popolazioni-CNR, Alghero, Italy"^^xsd:string ; pubblicazioni:titolo "Meta-analysis of genome-wide linkage studies for multiple sclerosis, using an extended GSMA method."^^xsd:string ; prodottidellaricerca:abstract "Many genome-wide linkage studies in multiple sclerosis (MS) have been performed, but results are disappointing, with linkage confirmed only in the HLA region. We combined results from all available, non-overlapping genome-wide linkage studies in MS using the Genome Search Meta-Analysis method (GSMA). The GSMA is a rank-based analysis, which assesses the strongest evidence for linkage within bins of traditionally 30 cM width on the autosomes and X chromosome. Genome-wide evidence for linkage was confirmed on chromosome 6p (HLA region; P=0.00004). Suggestive evidence for linkage was found on chromosomes 10q (P=0.0077), 18p (P=0.0054) and 20p (P=0.0079). To explore how these results could be affected by bin definition, we analysed the data using different bin widths (20 and 40 cM) and using a shifted 30 cM bin by moving bin boundaries by 15 cM. Consistently significant results were obtained for the 6p region. The regions on 10q and 18p provided suggestive evidence for linkage in some analyses, and, interestingly, a region on 6q, that showed only nominal significance in the original analysis, yielded increased, suggestive significance in two of the additional analyses. These regions may provide targets to focus candidate gene studies or to prioritise results from genome-wide association studies." ; prodottidellaricerca:prodottoDi modulo:ID2534 , istituto:CDS038 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8201 . ns11:ID239010 pubblicazioni:rivistaDi prodotto:ID26354 .