@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA7374 pubblicazioni:autoreCNRDi prodotto:ID24122 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID24122 . unitaDiPersonaleInterno:MATRICOLA8489 pubblicazioni:autoreCNRDi prodotto:ID24122 . @prefix modulo: . modulo:ID7326 prodottidellaricerca:prodotto prodotto:ID24122 . @prefix rdf: . @prefix retescientifica: . prodotto:ID24122 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID24122 rdfs:label "Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID24122 pubblicazioni:anno "2009-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.peptides.2009.06.013"^^xsd:string . @prefix skos: . prodotto:ID24122 skos:altLabel "
Del Ry S, Cabiati M, Lionetti V, Simioniuc A, Caselli C, Prescimone T, Emdin M, Giannessi D (2009)
Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
in Peptides (New York, NY : 1980)
"^^rdf:HTML ; pubblicazioni:autori "Del Ry S, Cabiati M, Lionetti V, Simioniuc A, Caselli C, Prescimone T, Emdin M, Giannessi D"^^xsd:string ; pubblicazioni:paginaInizio "1710"^^xsd:string ; pubblicazioni:paginaFine "1713"^^xsd:string ; pubblicazioni:numeroVolume "30"^^xsd:string . @prefix ns11: . prodotto:ID24122 pubblicazioni:rivista ns11:ID417037 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "CNR, Inst Clin Physiol, I-56124 Pisa, Italy\nCNR Reg Toscana, G Monasterio Fdn, Pisa, Italy\nScuola Super Sant Anna, Sector Med, Pisa, Italy"^^xsd:string ; pubblicazioni:titolo "Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure"^^xsd:string ; prodottidellaricerca:abstract "High-frequency pacing of the left ventricle (LV) free wall causes a dyssynchronous pattern of contraction that leads to progressive heart failure (HF) with pronounced differences in regional contractility. Aim of this study was to evaluate possible changes in brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) mRNA expression in the anterior/anterior lateral region (pacing site, PS) as compared to the infero-septal region (opposite site. OS) and to explore possible association between the contractiling pattern and biomarker expression. Cardiac tissue was collected from minipigs with pacing-induced HF (n = 8) and without (control, n = 6). The samples were selectively harvested from the anterior left ventricular (LV) wall, PS, and from an area remote to the pacing-site, OS. BNP and CNP mRNA expression was evaluated by semi-quantitative polymerase chain reaction (PCR). A significant difference in BNP expression was found in the PS between HF animals and controls (BNP/GAPDH: 0.65 +/- 0.11 vs. 0.35 +/- 0.04, p = 0.02), but not in the OS (BNP/GAPDH: 0.36 +/- 0.05, ns vs. controls). CNP expression was not different compared to controls, although higher levels were observed in the PS and in the OS with respect to the controls (CNP/GAPDH: controls 0.089 +/- 0.036, PS 0.289 +/- 0.23, OS 0.54 +/- 0.16). This finding was in tune with an increase of CNP tissue concentration (controls: 0.69 +/- 0.13; PS = 1.56 +/- 0.19: OS = 1.70 +/- 0.42 pg/mg protein; p = 0.039 controls vs. OS). Higher BNP mRNA expression in the PS is consistent with a reduction in contractile function in this region, while higher CNP mRNA expression in the OS suggests the presence of concomitant endothelial dysfunction in the remote region. (C) 2009 Elsevier Inc"@en ; prodottidellaricerca:prodottoDi istituto:CDS035 , modulo:ID7326 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA7374 , unitaDiPersonaleInterno:MATRICOLA8489 . ns11:ID417037 pubblicazioni:rivistaDi prodotto:ID24122 .