@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID24017 . @prefix modulo: . modulo:ID7085 prodottidellaricerca:prodotto prodotto:ID24017 . @prefix rdf: . prodotto:ID24017 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID24017 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID24017 rdfs:label "Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures (Articolo in rivista)"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID24017 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID24017 skos:altLabel "
Canistro D.; Pozzetti L.; Sapone A.; Broccoli M.; Affatato A.; Stradiotti A.; Longo V.; Menichini P.; Barale R.; Paolini M. (2008)
Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures
in Food and chemical toxicology
"^^rdf:HTML ; pubblicazioni:autori "Canistro D.; Pozzetti L.; Sapone A.; Broccoli M.; Affatato A.; Stradiotti A.; Longo V.; Menichini P.; Barale R.; Paolini M."^^xsd:string ; pubblicazioni:paginaInizio "34"^^xsd:string ; pubblicazioni:paginaFine "42"^^xsd:string ; pubblicazioni:numeroVolume "46"^^xsd:string . @prefix ns10: . prodotto:ID24017 pubblicazioni:rivista ns10:ID435920 ; pubblicazioni:note "In: Food and Chemical Toxicology, vol. 46 pp. 34 - 42. Elsevier, 2008."^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Pharmacology, Molecular Toxicology Unit, Alma Mater Studiorum-University of Bologna, Bologna,Italy. Laboratory of Pharmacogenetic and Drug Metabolism, CNR Clinical Physiology Institute, Pisa,Italy. Department of Human and Environmental Sciences,University of Pisa, Pisa,Italy, CNR-IFC, Pisa"^^xsd:string ; pubblicazioni:titolo "Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures"^^xsd:string ; prodottidellaricerca:abstract "It was previously found that fenarimol,vinclozolin or acephate,three of the most used pesticides worldwide,provoked a marked per- turbation of murine cytochrome P450 (CYP)-linked monooxygenases.Here,to more closely mimic human exposure,it was investigated whether di ?erent pesticide combinations administered i .p .in male Swiss Albino CD1 mice in single or repeated fashion (daily,for three consecutive days),a ?ect CYP-dependent oxidations.The four simulated mixtures showed a complex pattern of CYP induction and suppression,especially after repeated injection.For example,while fenarimol alone was the most inducing agent -reaching a 79-fold increase over control in testosterone 2 a hydroxylase -followed by vinclozolin and acephate,coadministration with the former markedly reduced induction.Coadministration with vinclozolin,determined various positive and negative modulations.An increase of CYP2B1/2 and CYP3A1/2-associated oxidases and a decrease of ethoxycoumarin metabolism was observed in the acephate and vinclozolin mixture. An equivalent or reduced CYP expression,if compared to double combinations,was seen using the complete mixture.Taken as a whole, the unpredictability of the recorded e ?ects with simple mixtures,shrinks the misleading extrapolation performed on a single pesticide.If reproduced in human,such changes,altering either endogenous metabolism or biotransformation of ubiquitous toxins,might have public health implications." ; prodottidellaricerca:prodottoDi modulo:ID7085 , istituto:CDS035 . @prefix parolechiave: . prodotto:ID24017 parolechiave:insiemeDiParoleChiave . ns10:ID435920 pubblicazioni:rivistaDi prodotto:ID24017 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID24017 .