@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID4970 pubblicazioni:autoreCNRDi prodotto:ID23993 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID23993 . @prefix modulo: . modulo:ID7079 prodottidellaricerca:prodotto prodotto:ID23993 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA8082 pubblicazioni:autoreCNRDi prodotto:ID23993 . @prefix rdf: . @prefix retescientifica: . prodotto:ID23993 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID23993 rdfs:label "Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage; Reversed by Increases in pAMPK, Heme Oxygenase-1 and Adiponectin (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID23993 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID23993 skos:altLabel "
Sambuceti G.; Morbelli S.; Vanella L.; Kusmic C.; Marini C.; Massollo M.; Augeri C.; Corselli M.; Ghersi C.; Chiavarini B.; Rodella L. F.; L'Abbate A.; Drummond G.; Abraham N. A.; Frassoni F. (2008)
Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage; Reversed by Increases in pAMPK, Heme Oxygenase-1 and Adiponectin
in Stem cells (Dayt. Ohio)
"^^rdf:HTML ; pubblicazioni:autori "Sambuceti G.; Morbelli S.; Vanella L.; Kusmic C.; Marini C.; Massollo M.; Augeri C.; Corselli M.; Ghersi C.; Chiavarini B.; Rodella L. F.; L'Abbate A.; Drummond G.; Abraham N. A.; Frassoni F."^^xsd:string ; pubblicazioni:paginaInizio "399"^^xsd:string ; pubblicazioni:paginaFine "407"^^xsd:string ; pubblicazioni:numeroVolume "27"^^xsd:string . @prefix ns12: . prodotto:ID23993 pubblicazioni:rivista ns12:ID240188 ; pubblicazioni:note "In: Stem Cells, vol. epub nov 2008 article n. 10.1634/stemcells.2008-0. Alpha Med Press, 2008."^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Internal Medicine, Division of Nuclear Medicine, University of Genoa, Genova, Italy, New York Medical College, USA, CNR-IFC, Pisa, Centro Cellule Staminali e Terapia Cellulare, S. Martino Hospital, Genova, Department of Biomedical Science3, University of Brescia, Scuola Superiore S. Anna, Pisa, Italy and CNR Institute of Clinical Physiology Pisa, Italy"^^xsd:string ; pubblicazioni:titolo "Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage; Reversed by Increases in pAMPK, Heme Oxygenase-1 and Adiponectin"^^xsd:string ; prodottidellaricerca:abstract "Background: Atherosclerosis progression is accelerated in diabetes (DM) either by direct endothelial damage or a reduction in availability and function of endothelial progenitor cells (EPCs). Both alterations are related to increased oxidant damage. Aim: We examined if DM specifically impairs vascular signalling thereby reducing the recruitment of normal EPCs, and if increases in antioxidant levels by induction of heme oxygenase-1 (HO-1) can reverse this condition. Methods: Control and diabetic rats were treated with the HO-1 inducer cobalt protoporphyrin (CoPP,0.5 mg/100 g/bw) once a week for three weeks. Eight weeks after development of diabetes 2 X106 EPCs harvested from aorta of syngenic inbred normal rats and labelled with 1.85 MBq of 99mTc-exametazime were infused via the femoral vein to estimate their blood clearance and aortic recruitment. Circulating endothelial cells and the aortic expression of thrombomodulin, CD31 and eNOS measured endothelial damage. Results: DM reduced blood clearance and aortic recruitment of EPCs. Both parameters were returned to control levels by CoPP treatment without affecting EPCs kinetics in normal animals. These abnormalities of EPCs in DM were paralleled by reduced serum adiponectin levels, increased numbers of circulating endothelial cells, reduced endothelial expression of peNOS, reduced levels of thrombomodulin (TM), CD31 and pAMPK. CoPP treatment restored all of these parameters to normal levels. Conclusion: Type II DM and its related oxidant damage hamper the interaction between the vascular wall and normal EPCs by mechanisms that are, at least partially, reversed by the induction of HO-1 gene expression, adiponectin and pAMPK levels." ; prodottidellaricerca:prodottoDi modulo:ID7079 , istituto:CDS035 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID4970 , unitaDiPersonaleInterno:MATRICOLA8082 . @prefix parolechiave: . prodotto:ID23993 parolechiave:insiemeDiParoleChiave . ns12:ID240188 pubblicazioni:rivistaDi prodotto:ID23993 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID23993 .