@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS040 prodottidellaricerca:prodotto prodotto:ID237020 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA8456 pubblicazioni:autoreCNRDi prodotto:ID237020 . unitaDiPersonaleInterno:MATRICOLA19625 pubblicazioni:autoreCNRDi prodotto:ID237020 . @prefix modulo: . modulo:ID2698 prodottidellaricerca:prodotto prodotto:ID237020 . @prefix rdf: . prodotto:ID237020 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID237020 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID237020 rdfs:label "A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID237020 pubblicazioni:anno "1996-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/0921-8777(96)00014-6"^^xsd:string . @prefix skos: . prodotto:ID237020 skos:altLabel "
Bush DB, Zdzienicka M, Natarajan AT, Jones NJ, Overkamps WIJ, Collins A, Mitchell D, Stefanini M, Botta E, Bliss AR, Liu N, White D, van Gool AJ and Thompson LH (1996)
A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity
in Mutation research. DNA repair (Print); Elsevier Science Publishers, Amsterdam (Paesi Bassi)
"^^rdf:HTML ; pubblicazioni:autori "Bush DB, Zdzienicka M, Natarajan AT, Jones NJ, Overkamps WIJ, Collins A, Mitchell D, Stefanini M, Botta E, Bliss AR, Liu N, White D, van Gool AJ and Thompson LH"^^xsd:string ; pubblicazioni:paginaInizio "209"^^xsd:string ; pubblicazioni:paginaFine "221"^^xsd:string ; pubblicazioni:numeroVolume "363"^^xsd:string . @prefix ns11: . prodotto:ID237020 pubblicazioni:rivista ns11:ID506556 ; pubblicazioni:numeroFascicolo "3"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Stefanini, Botta: IGBE CNR Pavia\nBush, Bliss, White: Armed Forces Inst Pathol, Washington, DC\nZdzienicka, Natarajan, Overkamp: Leiden University NL\nJones: University of Liverpool UK\nMitchell:UTMD Anderson Cancer Center, Smithville,TX\nCollins: Rowett Res Inst, Aberdeen, Scotland\nVan Gool: Erasmus University, Rotterdam NL\nLiu, Thompson: Lawrence Livermore National Laboratory, Livermore, CA"^^xsd:string ; pubblicazioni:titolo "A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity"^^xsd:string ; prodottidellaricerca:abstract "A new mitomycin C (MMC)-sensitive rodent line, UV40, has been identified in the collection of ultraviolet light-(UV-) sensitive mutants of Chinese hamster ovary (CHO) cells isolated at the previous Facility for Automated Experiments in Cell Biology (FAECB). It was isolated from an UV mutant hunt using mutagenesis of AA8 cells with the DNA intercalating frameshift mutagen ICR170. It is complemented by CHO-UV-1, irs1, irs3, irs1SF, MC5, V-C8 and V-H4 with respect to its MMC sensitivity based on cell survival. Despite having approx, 4 x normal UV sensitivity and increased sensitivity to UV inhibition of DNA replication, it has near-normal incision kinetics of UV irradiated DNA, and normal (6-4) photoproducts removal. It also is not hypermutable by UV, and shows near normal levels of UV inhibition of RNA synthesis. UV40 also has approx, 11X, 10x, 5x and 2x AA8 sensitivity to MMC, ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS), and X-rays, respectively. Thus, its defect apparently does not involve nucleotide excision repair but rather another process, possibly in replicating past lesions. The spontaneous chromosomal aberration frequency is elevated to 20% in UV40, and the baseline frequency of sister chromatid exchange is also similar to 4-fold increased. The phenotype of UV40 appears to differ from all other rodent mutants that have so far been described."@en . @prefix ns12: . prodotto:ID237020 pubblicazioni:editore ns12:ID12445 ; prodottidellaricerca:prodottoDi modulo:ID2698 , istituto:CDS040 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19625 , unitaDiPersonaleInterno:MATRICOLA8456 . ns12:ID12445 pubblicazioni:editoreDi prodotto:ID237020 . ns11:ID506556 pubblicazioni:rivistaDi prodotto:ID237020 .