@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID23477 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA18146 pubblicazioni:autoreCNRDi prodotto:ID23477 . unitaDiPersonaleInterno:MATRICOLA8507 pubblicazioni:autoreCNRDi prodotto:ID23477 . unitaDiPersonaleInterno:MATRICOLA29467 pubblicazioni:autoreCNRDi prodotto:ID23477 . @prefix rdf: . @prefix retescientifica: . prodotto:ID23477 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID23477 rdfs:label "Therapeutic effect of diagnostic ultrasound on enzymatic thrombolysis. An in vitro study on blood of normal subjects and patients with coronary disease (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID23477 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1160/TH03-11-0684"^^xsd:string . @prefix skos: . prodotto:ID23477 skos:altLabel "
Basta G., Lupi C., Lazzerini G., Chiarelli P., L'Abbate A., Rovai D. (2004)
Therapeutic effect of diagnostic ultrasound on enzymatic thrombolysis. An in vitro study on blood of normal subjects and patients with coronary disease
in Thrombosis and haemostasis
"^^rdf:HTML ; pubblicazioni:autori "Basta G., Lupi C., Lazzerini G., Chiarelli P., L'Abbate A., Rovai D."^^xsd:string ; pubblicazioni:paginaInizio "1078"^^xsd:string ; pubblicazioni:paginaFine "1083"^^xsd:string ; pubblicazioni:numeroVolume "91"^^xsd:string . @prefix ns10: . prodotto:ID23477 pubblicazioni:rivista ns10:ID347480 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "CNR, Inst Clin Physiol, Pisa, Italy\nScuola Superiore S Anna, Pisa, Italy"^^xsd:string ; pubblicazioni:titolo "Therapeutic effect of diagnostic ultrasound on enzymatic thrombolysis. An in vitro study on blood of normal subjects and patients with coronary disease"^^xsd:string ; prodottidellaricerca:abstract "If delivered at elevated intensity, ultrasound potentiates enzymatic clot dissolution; however, an elevated acoustic intensity damages vascular wall and favors reocclusion. This study's aim was to investigate whether exposure to high-frequency, low-intensity ultrasound - generated by a diagnostic scanner enhances enzymatic thrombolysis, and if this effect differs in clots from blood of normal subjects and of patients with coronary artery disease (CAD). Venous blood samples were drawn from 10 healthy volunteers and from 10 CAD patients on chronic medical treatment, which also included aspirin. Each sample generated 2 radiolabelled clots, which were positioned in 2 in vitro models filled with human plasma recirculating at 37degrees. One clot was exposed to acetyl salicylic acid (60 mug/ml), tissue plasminogen activator (3 mug/ml) and heparin (I IU/ml), while the other was exposed to the same medications plus ultrasound (2.5 MHz, mechanical index = 1.0) for 3 hours. Enzymatic thrombolysis was measured as solubilization of radiolabel. Normal subjects and patients did not significantly differ as to coagulation parameters, weight, volume and density of the clots, and fibrinolytic activity (p = 0.794). Ultrasound exposure did not influence thrombolysis in clots of normal subjects (p = 0.367), while it enhanced the dissolution of clots of CAD patients (p = 0.013). The enhancement was equal to 51% at 5 minutes, 32% at 15 minutes, 27% at 30 minutes, 20% at 1 hour and 19% at 3 hours (p < 0.05). Diagnostic ultrasound enhances enzymatic dissolution of clots generated from the blood of CAD patients, likely due to chronic treatment and in particular to aspirin."@en ; prodottidellaricerca:prodottoDi istituto:CDS035 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8507 , unitaDiPersonaleInterno:MATRICOLA18146 , unitaDiPersonaleInterno:MATRICOLA29467 . @prefix parolechiave: . prodotto:ID23477 parolechiave:insiemeDiParoleChiave . ns10:ID347480 pubblicazioni:rivistaDi prodotto:ID23477 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID23477 .