@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID2476 pubblicazioni:autoreCNRDi prodotto:ID230421 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID230421 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA8825 pubblicazioni:autoreCNRDi prodotto:ID230421 . @prefix modulo: . modulo:ID8672 prodottidellaricerca:prodotto prodotto:ID230421 . unitaDiPersonaleInterno:MATRICOLA8928 pubblicazioni:autoreCNRDi prodotto:ID230421 . @prefix rdf: . @prefix retescientifica: . prodotto:ID230421 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID230421 rdfs:label "Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID230421 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1007/s00259-008-0729-x"^^xsd:string . @prefix skos: . prodotto:ID230421 skos:altLabel "
Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappat\u00E0 S, Salvatore M. (2008)
Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT.
in European journal of nuclear medicine and molecular imaging (Print)
"^^rdf:HTML ; pubblicazioni:autori "Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappat\u00E0 S, Salvatore M."^^xsd:string ; pubblicazioni:paginaInizio "1343"^^xsd:string ; pubblicazioni:paginaFine "1349"^^xsd:string ; pubblicazioni:numeroVolume "35"^^xsd:string . @prefix ns12: . prodotto:ID230421 pubblicazioni:rivista ns12:ID69266 ; pubblicazioni:pagineTotali "7"^^xsd:string ; pubblicazioni:numeroFascicolo "7"^^xsd:string ; pubblicazioni:affiliazioni "Biostructure and Bioimaging Institute, National Research Council/Department of Biomorphological and Functional Sciences, University Federico II, Napoli, Italy"^^xsd:string ; pubblicazioni:titolo "Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT."^^xsd:string ; prodottidellaricerca:abstract "BACKGROUND:\n\nDual-head SPECT systems are used by many clinical departments for [(123)I]FP-CIT SPECT imaging, while triple-head or brain-dedicated systems with better imaging performance are more commonly used by research institutions. There are limited data comparing the capability of the two types of system to measure dopamine transporter (DAT) loss in vivo.\nPURPOSE:\n\nThe aim of this study was to compare the ability of a dual-head and a brain-dedicated SPECT system to estimate the degree of DAT loss in different movement disorders with variable nigrostriatal impairment, with [(123)I]FP-CIT.\nMATERIALS AND METHODS:\n\nFour patients with essential tremor, 24 with Parkinson's disease (PD), six with spinocerebellar ataxia type 2 and six controls were studied with [(123)I]FP-CIT. SPECT scans were performed on a dual-head (E.CAM-Siemens) and subsequently on a brain-dedicated system (Ceraspect-DSI).\nRESULTS:\n\nStriatal DAT outcome measures on the E.CAM and the Ceraspect were strongly correlated and the putamen-to-caudate ratios were almost identical. Although the measured values were lower by 52+/-25% in caudate and by 51+/-31% in putamen on the E.CAM (p<0.0001), the average striatal DAT decrease in each patient group compared with controls was similar for both systems. In PD patients, similar correlations (p<0.05) were found between motor UPDRS or Hoehn and Yahr stage and striatal DAT density.\nCONCLUSIONS:\n\nDespite underestimation of striatal DAT outcome measures, the E.CAM showed similar capability as the Ceraspect in measuring the degree of nigrostriatal dopaminergic deficit and assessing the correlation between DAT outcome measures and clinical variables of PD severity and stage."@en ; prodottidellaricerca:prodottoDi modulo:ID8672 , istituto:CDS017 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID2476 , unitaDiPersonaleInterno:MATRICOLA8825 , unitaDiPersonaleInterno:MATRICOLA8928 . ns12:ID69266 pubblicazioni:rivistaDi prodotto:ID230421 .