@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS044 prodottidellaricerca:prodotto prodotto:ID222336 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID21250 pubblicazioni:autoreCNRDi prodotto:ID222336 . @prefix modulo: . modulo:ID4154 prodottidellaricerca:prodotto prodotto:ID222336 . @prefix rdf: . prodotto:ID222336 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID222336 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID222336 rdfs:label "Gene autoregulation via intronic microRNAs and its functions (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID222336 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1186/1752-0509-6-131"^^xsd:string . @prefix skos: . prodotto:ID222336 skos:altLabel "
El Baroudi Mariama, Bosia Carla, Osella Matteo, Cor\u00E0 Davide, Caselle Michele (2012)
Gene autoregulation via intronic microRNAs and its functions
in BMC systems biology; Biomed Central Ltd., London (Regno Unito)
"^^rdf:HTML ; pubblicazioni:autori "El Baroudi Mariama, Bosia Carla, Osella Matteo, Cor\u00E0 Davide, Caselle Michele"^^xsd:string ; pubblicazioni:paginaInizio "1"^^xsd:string ; pubblicazioni:paginaFine "16"^^xsd:string ; pubblicazioni:altreInformazioni "ID_PUMA: cnr.iit/2012-A0-016"^^xsd:string ; pubblicazioni:numeroVolume "6"^^xsd:string . @prefix ns11: . prodotto:ID222336 pubblicazioni:rivista ns11:ID109885 ; pubblicazioni:numeroFascicolo "131"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "CNR-IIT, Pisa, Italy; University of Torino, Italy; Universit\u00E9 Pierre et Marie Curie, Paris; University of Torino, Italy; University of Torino, Italy"^^xsd:string ; pubblicazioni:titolo "Gene autoregulation via intronic microRNAs and its functions"^^xsd:string ; prodottidellaricerca:abstract "Background. MicroRNAs, post-transcriptional repressors of gene expression, play a pivotal role in gene regulatory networks. They are involved in core cellular processes and their dysregulation is associated to a broad range of human diseases. This paper focus on a minimal microRNA-mediated regulatory circuit, in which a protein-coding gene (host gene) is targeted by a microRNA located inside one of its introns. Results. Autoregulation via intronic microRNAs is widespread in the human regulatory network, as confirmed by our bioinformatic analysis, and can perform several regulatory tasks despite its simple topology. Our analysis, based on analytical calculations and simulations, indicates that this circuitry alters the dynamics of the host gene expression, can induce complex responses implementing adaptation and Weber?s law, and efficiently filters fluctuations propagating from the upstream network to the host gene. A fine-tuning of the circuit parameters can optimize each of these functions. Interestingly, they are all related to gene expression homeostasis, in agreement with the increasing evidence suggesting a role of microRNA regulation in conferring robustness to biological processes. In addition to model analysis, we present a list of bioinformatically predicted candidate circuits in human for future experimental tests. Conclusions. The results presented here suggest a potentially relevant functional role for negative self-regulation via intronic microRNAs, in particular as a homeostatic control mechanism of gene expression. Moreover, the map of circuit functions in terms of experimentally measurable parameters, resulting from our analysis, can be a useful guideline for possible applications in synthetic biology."@en . @prefix ns12: . prodotto:ID222336 pubblicazioni:editore ns12:ID2219 ; prodottidellaricerca:prodottoDi modulo:ID4154 , istituto:CDS044 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID21250 . @prefix parolechiave: . prodotto:ID222336 parolechiave:insiemeDiParoleChiave . ns12:ID2219 pubblicazioni:editoreDi prodotto:ID222336 . ns11:ID109885 pubblicazioni:rivistaDi prodotto:ID222336 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID222336 .