@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS014 prodottidellaricerca:prodotto prodotto:ID219130 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA5615 pubblicazioni:autoreCNRDi prodotto:ID219130 . @prefix rdf: . @prefix retescientifica: . prodotto:ID219130 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID219130 rdfs:label "Modulation of rat peritoneal mast cell and human basophil histamine release by estrogens. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID219130 pubblicazioni:anno "1990-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID219130 skos:altLabel "
Cocchiara R, Albeggiani G, Di Trapani G, Azzolina A, Lampiasi N, Rizzo F, Geraci D. (1990)
Modulation of rat peritoneal mast cell and human basophil histamine release by estrogens.
in International archives of allergy and applied immunology
"^^rdf:HTML ; pubblicazioni:autori "Cocchiara R, Albeggiani G, Di Trapani G, Azzolina A, Lampiasi N, Rizzo F, Geraci D."^^xsd:string ; pubblicazioni:paginaInizio "192"^^xsd:string ; pubblicazioni:paginaFine "197"^^xsd:string ; pubblicazioni:numeroVolume "93"^^xsd:string . @prefix ns10: . prodotto:ID219130 pubblicazioni:rivista ns10:ID293962 ; pubblicazioni:affiliazioni "IBIM"^^xsd:string ; pubblicazioni:titolo "Modulation of rat peritoneal mast cell and human basophil histamine release by estrogens."^^xsd:string ; prodottidellaricerca:abstract "This study was undertaken to investigate the effect of estrogens on the histamine release mediated by IgE in rat peritoneal mast cells (PMC) and in sensitized human basophils. The estrogens were found to enhance the histamine release of either rat PMC and sensitized human basophils upon stimulation with anti-IgE. The enhancement was estrogens dose-dependent reaching the maximum value of 23% for rat PMC and 41% for sensitized human basophils stimulated with anti-IgE upon preincubation with 10(-8) M estrogens. Moreover, when purified PMC were used, the enhancing effect was still detected, suggesting a direct interaction between estrogens and mast cells. The enhancing effect took place quite rapidly reaching plateau levels in about 60 min. Basophils preincubated at 4 instead of 37 degrees C did not give any appreciable enhancement, suggesting that it was temperature-dependent and that the effect observed was not due to cytotoxicity. Incubation of PMC or human basophils with estrogens alone, without challenge with anti-IgE, did not give any detectable histamine release. The enhancement of histamine release by estrogens is probably mediated by IgE molecules present on the cell membrane, since this effect was not observed on challenge with substance P or compound 48/80, two segretagogues known to induce histamine release not via IgE."@en ; prodottidellaricerca:prodottoDi istituto:CDS014 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA5615 . ns10:ID293962 pubblicazioni:rivistaDi prodotto:ID219130 .