@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8920 pubblicazioni:autoreCNRDi prodotto:ID215236 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID215236 . unitaDiPersonaleInterno:MATRICOLA9188 pubblicazioni:autoreCNRDi prodotto:ID215236 . unitaDiPersonaleInterno:MATRICOLA10726 pubblicazioni:autoreCNRDi prodotto:ID215236 . @prefix modulo: . modulo:ID2659 prodottidellaricerca:prodotto prodotto:ID215236 . unitaDiPersonaleInterno:MATRICOLA12872 pubblicazioni:autoreCNRDi prodotto:ID215236 . @prefix rdf: . prodotto:ID215236 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID215236 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID215236 rdfs:label "Impact of (18)F-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID215236 pubblicazioni:anno "2013-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.nucmedbio.2013.02.009"^^xsd:string . @prefix skos: . prodotto:ID215236 skos:altLabel "
Storto G, Gallicchio R, Pellegrino T, Nardelli A, De Luca S, Capacchione D, Sirignano C, Pace L. (2013)
Impact of (18)F-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP
in Nuclear medicine and biology
"^^rdf:HTML ; pubblicazioni:autori "Storto G, Gallicchio R, Pellegrino T, Nardelli A, De Luca S, Capacchione D, Sirignano C, Pace L."^^xsd:string ; pubblicazioni:paginaInizio "518"^^xsd:string ; pubblicazioni:paginaFine "523"^^xsd:string ; pubblicazioni:numeroVolume "40"^^xsd:string . @prefix ns11: . prodotto:ID215236 pubblicazioni:rivista ns11:ID238851 ; pubblicazioni:pagineTotali "6"^^xsd:string ; pubblicazioni:numeroFascicolo "4"^^xsd:string ; pubblicazioni:affiliazioni "IRCCS, CROB, Rionero in Vulture, Italy\nIstituto di Biostrutture e Bioimmagini - CNR, NAPOLI"^^xsd:string ; pubblicazioni:titolo "Impact of (18)F-fluoride PET-CT on implementing early treatment of painful bone metastases with Sm-153 EDTMP"^^xsd:string ; prodottidellaricerca:abstract "This study evaluated the diagnostic impact of using skeletal (18)F-fluoride PET/CT on patients with painful bone metastases to schedule an early palliative radionuclide treatment. Methods: The skeletal involvement from prostate cancer metastases was assessed by both (99m)Tc-diphosphonate bone scan (BS) and (18)F-fluoride PET/CT within four weeks in 24 patients (67.7\u00B15.1years) suffering from a borderline degree of bone pain for which radionuclide palliation was not shortly planned for administration. The BS and (18)F-fluoride PET/CT results were compared, assessing the number and extension of the skeletal sites involved. Afterward, the patients were randomly assigned either to the study group (N=12) receiving radionuclide therapy (Samarium-153 EDTMP) or to the control group (N=12) not receiving radionuclide therapy. The short-term results from the radionuclide palliation group (evaluated with a visual analogue scale) were compared with the controls. Results: Overall, at BS, 7.6\u00B11.4 sites were considered metastatic, involving at least 5\u00B11 body regions. At (18)F-fluoride PET/CT, 116\u00B119 sites presented metastatic involvement with 12/12 body regions concerned. No differences were found in regards to either the number of metastatic sites or regions at both BS and (18)F-fluoride PET/CT between the study group and controls (p=ns). At CT, 88 blastic metastases were identified, whereas 110 were mainly lytic. Most of mainly lytic lesions were not detectable at BS. The reduction in total discomfort and bone pain in the study group was significantly greater than in the controls (p<0.0001). Conclusion: Sm-153 EDTMP therapy should be considered for patients with early bone pain from prostate cancer even if their BS only indicates a few metastases before the initiation of a severe pain syndrome. (18)F-fluoride PET/CT may be helpful in deciding if the implementation of bone pain palliation using bone-seeking radionuclides at pain onset is necessary."@en ; prodottidellaricerca:prodottoDi istituto:CDS017 , modulo:ID2659 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA10726 , unitaDiPersonaleInterno:MATRICOLA12872 , unitaDiPersonaleInterno:MATRICOLA8920 , unitaDiPersonaleInterno:MATRICOLA9188 . ns11:ID238851 pubblicazioni:rivistaDi prodotto:ID215236 .