@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA16239 pubblicazioni:autoreCNRDi prodotto:ID210044 . unitaDiPersonaleInterno:MATRICOLA8852 pubblicazioni:autoreCNRDi prodotto:ID210044 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS038 prodottidellaricerca:prodotto prodotto:ID210044 . @prefix rdf: . prodotto:ID210044 rdf:type prodotto:TIPO1302 . @prefix retescientifica: . prodotto:ID210044 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID210044 rdfs:label "Environmental and Lifestyle Factors Involved in Normal Hearing Function and Age-Related Hearing Loss (Abstract/Poster in atti di convegno)"@en . @prefix xsd: . prodotto:ID210044 pubblicazioni:anno "2013-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID210044 skos:altLabel "
Giorgia Girotto1, Dragana Vuckovic1, Ginevra Biino2, Francesco Panu3, Mario Pirastu4, Paolo Gasparini1 (2013)
Environmental and Lifestyle Factors Involved in Normal Hearing Function and Age-Related Hearing Loss
in 36th Annual MidWinter Meeting of the Association for Research in Otolaryngology, Baltimore, Maryland, USA, February 16-20, 2013
"^^rdf:HTML ; pubblicazioni:autori "Giorgia Girotto1, Dragana Vuckovic1, Ginevra Biino2, Francesco Panu3, Mario Pirastu4, Paolo Gasparini1"^^xsd:string ; pubblicazioni:paginaInizio "353"^^xsd:string ; pubblicazioni:paginaFine "353"^^xsd:string ; pubblicazioni:url "http://www.aro.org/ARO2013_FinalProgramBook.pdf.pdf"^^xsd:string ; pubblicazioni:titoloVolume "ARO Abstract"^^xsd:string ; pubblicazioni:numeroVolume "36"^^xsd:string ; pubblicazioni:pagineTotali "1"^^xsd:string ; skos:note "Poster"^^xsd:string ; pubblicazioni:affiliazioni "1 Med Genet, IRCCS-Burlo Garofolo Children Hospital, Trieste Univ, Trieste, Italy, 2 Institute of Molecular Genetics, Pavia, CNR, 3 Unit\u00E0 Operativa di Otorinolaringoiatria Ospedale Brotzu, Cagliari, 4 Institution of population Genetics, CNR, Sassari, Italy"^^xsd:string ; pubblicazioni:titolo "Environmental and Lifestyle Factors Involved in Normal Hearing Function and Age-Related Hearing Loss"^^xsd:string ; prodottidellaricerca:abstract "Background\nUntil now, little is known about environmental/lifestyle factors underlying normal hearing function and age-related hearing loss (ARHL). To reach this goal we decided to run an epidemiological study on hearing quantitative and qualitative traits (analysing the low, medium and high Pure Tone Average-PTA) on subjects coming from several isolated populations from Europe, Caucasus and Central Asia.\nMethods\n4401 subjects coming from Europe (Italy, Croatia and Ukraine), Caucasus (Armenia, Azerbaijan, Georgia) and Central Asia (Uzbekistan, Kazakhstan, Tajikistan and Kirghizstan) and ranging from 4 to 95 years were included in the analysis. Different thresholds (0.25, 0.5, 1, 2, 4, 8 kHz) as well as PTAs have been considered in the study. A medical examination has been performed in order to exclude pathological conditions related to the hearing impairment. A series of lifestyle/environmental factors have been tested including habits (smoking, drinking, etc.), diet (several foods and beverages intakes), level of education, etc. A model based on linear/logistic regression was used to fit PTAs to all the covariates (smoking, chocolate, coffee, tea, wine, beer, dairy products, hard-liquor) including sex and age. \nResults\nAs regards hearing function, our results show, for the first time, that among eight analyzed variables only coffee consumption (but not the coffee intake) was strongly associated with better normal hearing function in particular at low and high frequencies in four out of ten countries investigated (p=0.038 in Sardinia, 0.006 in Southern Italy, 0.017 in Azerbaijan, 0.016 in Tajikistan). As represented in the Figure 1, in the coffee-drinkers, the hearing function improves on average of 5.01 dB in Tajikistan. No association was found in the other populations, neither with other substances or coffee intake. In this light, we might suppose a connection between specific populations/communities, genes and environment.\nAs regards ARHL phenotype, we found a strong association in two Italian isolated populations (p=0.02 for Sardinia, and p=0.05 for Southern Italy), in which a lower level of education is associated to an increased susceptibility to ARHL (Figure 2). \nConclusions\nThese data demonstrate, for the first time, a relationship between coffee consumption and a better hearing function, and confirm the relevance of a higher education in protecting against ARHL. The understanding of lifestyle/environmental risk factors will help us in developing new preventive strategies for ARHL."@en ; prodottidellaricerca:prodottoDi istituto:CDS038 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA16239 , unitaDiPersonaleInterno:MATRICOLA8852 .