@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID202772 . @prefix modulo: . modulo:ID7889 prodottidellaricerca:prodotto prodotto:ID202772 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID17932 pubblicazioni:autoreCNRDi prodotto:ID202772 . unitaDiPersonaleEsterno:ID18554 pubblicazioni:autoreCNRDi prodotto:ID202772 . @prefix rdf: . @prefix retescientifica: . prodotto:ID202772 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1305 . @prefix rdfs: . prodotto:ID202772 rdfs:label "Effects of baroreflex activities on IABP hemodynamics in a closed loop hybrid cardiovascular model (Abstract/Comunicazione in atti di convegno)"@en . @prefix xsd: . prodotto:ID202772 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID202772 skos:altLabel "
L. Fresiello, A. Di Molfetta, A.W. Khir, M. Kozarski, G. Ferrari (2011)
Effects of baroreflex activities on IABP hemodynamics in a closed loop hybrid cardiovascular model
in 38. annual ESAO & IV biennial IFAO congress, Porto, Portugal, 9 - 12 October 2011
"^^rdf:HTML ; pubblicazioni:autori "L. Fresiello, A. Di Molfetta, A.W. Khir, M. Kozarski, G. Ferrari"^^xsd:string ; pubblicazioni:paginaInizio "631"^^xsd:string ; pubblicazioni:paginaFine "631"^^xsd:string ; pubblicazioni:altreInformazioni "ID_PUMA: cnr.ifc/2011-A6-019"^^xsd:string ; pubblicazioni:url "http://www.artificial-organs.com/issue/ijao-vol-34-issue-8-august-2011-xxxviii-annual-esao-and-iv-biennial-ifao-congress"^^xsd:string ; pubblicazioni:numeroVolume "34"^^xsd:string . @prefix ns11: . prodotto:ID202772 pubblicazioni:rivista ns11:ID352459 ; pubblicazioni:numeroFascicolo "8"^^xsd:string ; skos:note "Abstract"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Clinical Physiology, CNR, Rome, Italy ; Na?ecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Science, Warsaw, Poland ; Department of Cardiology, University of Rome Tor Vergata, Rome, Italy ; Brunel Institute for Bioengineering, Brunel University, London, UK"^^xsd:string ; pubblicazioni:titolo "Effects of baroreflex activities on IABP hemodynamics in a closed loop hybrid cardiovascular model"^^xsd:string ; prodottidellaricerca:abstract "Objectives: Aim of this work is the integration of the autonomic mechanism of pressure regulation during temporary IABP assistance in a hybrid circulatory model. Methods: The hybrid model is based on merging computational and hydraulic models. The lumped parameter computational model includes the upper thoracic aorta, circulatory districts (upper body, kidneys, splanchnic, lower body, pulmonary, coronary circulation) and left/right hearts. The hydraulic model provides a representation of the lower thoracic aorta by a silicon rubber tube containing a 40cc IAB. An additional numerical module provides a representation of the baroreflex mechanism in terms of afferent and efferent sympathetic nerve activity (ANA, ENA). Baroreflex model acts as a feedback control loop that regulates the blood pressure by changing heart rate (HR), peripheral resistance and venous tone of each circulatory district. Experiments were conducted applying IABP assistance to a pathological circulatory condition. Results: The increment of diastolic pressure due to IABP provides an increment of ANA (+7%) and a decrement of ENA(-9%). Operating the IABP induced a reduction in HR by -6% (90 vs. 95 bpm), in kidney and upper body resistances by -5% (5.43 vs. 5.72 and 5.17 vs. 5.44 mmHg\u00B7s/mL, respectively). IABP also induced an increment in kidney flow by +7% (0.63 vs. 0.59 L/min) and upper body flow by +6.8% (0.50 vs. 0.46 L/min). By switching the IABP assistance frequency from 1:1 to 1:2 or 1:3 the mentioned effects reduce progressively. Results indicate that the short term effects of IAB are small, even in the presence of a model including baroreflex control. Conclusions: The model provides an instrument for the assessment of IABP effects on baroreflex mechanism due to the increase of mean diastolic blood pressure. This contributes to predict and study the global evolution of hemodynamic condition after IABP activation and the resultant change in organ flows."@en ; prodottidellaricerca:prodottoDi modulo:ID7889 , istituto:CDS035 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID18554 , unitaDiPersonaleEsterno:ID17932 . ns11:ID352459 pubblicazioni:rivistaDi prodotto:ID202772 .