@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA19901 pubblicazioni:autoreCNRDi prodotto:ID201954 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS035 prodottidellaricerca:prodotto prodotto:ID201954 . @prefix modulo: . modulo:ID7888 prodottidellaricerca:prodotto prodotto:ID201954 . unitaDiPersonaleInterno:MATRICOLA11322 pubblicazioni:autoreCNRDi prodotto:ID201954 . @prefix rdf: . prodotto:ID201954 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID201954 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID201954 rdfs:label "Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID201954 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.nucmedbio.2011.01.005"^^xsd:string . @prefix skos: . prodotto:ID201954 skos:altLabel "
SALVADORI, PIERO (1); Pascali, Giancarlo (1); Nannavecchia, Giovanni; Pitzianti, Sabrina (2011)
Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach
in Nuclear medicine and biology
"^^rdf:HTML ; pubblicazioni:autori "SALVADORI, PIERO (1); Pascali, Giancarlo (1); Nannavecchia, Giovanni; Pitzianti, Sabrina"^^xsd:string ; pubblicazioni:paginaInizio "637"^^xsd:string ; pubblicazioni:paginaFine "644"^^xsd:string ; pubblicazioni:numeroVolume "38"^^xsd:string . @prefix ns11: . prodotto:ID201954 pubblicazioni:rivista ns11:ID238851 ; pubblicazioni:pagineTotali "8"^^xsd:string ; pubblicazioni:numeroFascicolo "5"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "(1) CNR-IFC, Pisa"^^xsd:string ; pubblicazioni:titolo "Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach"^^xsd:string ; prodottidellaricerca:abstract "Introduction: The validation and confirmation of clinical usefulness of new and known positron emission tomography (PET) tracers require stable production routes and simple and robust radiochemical procedures. Microfluidic technologies are regarded as an approach that could allow an unprecedented flexibility and productivity in PET radiopharmaceutical research. In this work, we will show how a commercially available microfluidic system can be used for a sequential and repeatable radiosynthesis of three different fluorocholine analogues currently under investigation as tumor tracers. \n\nMethods: Advion microfluidic system was used for performing the synthesis and purification of [F-18]fluoromethyl, [F-18]fluoroethyl or [F-18]fluoropropyl choline employing a two-step approach, starting from the corresponding alkyl-ditosylate and reacting the [F-18]fluorotosylate obtained in the first step with neat dimethylethanolamine. The purification was obtained using a recyclable SPE cartridge set. \n\nResults: The three products, fluoromethylcholine, fluoroethylcholine and fluoropropylcholine, were obtained in good to optimum yields (22%-54% decay corrected) with a 15-min procedure. The production could be restarted several times for producing each one of the tracers without decrease in yields and purities, in accordance with a dose-on-demand (DOD) approach. The final products were formulated in isotonic saline solution. \n\nConclusion: The described approach gives a proof of principle of the enhanced productivity obtainable using a microfluidic approach; in particular, the possibility to produce the reported tracers in a DOD fashion following a homogeneous synthetic and purification approach will foster further studies on the clinical evaluation of the best fluorocholine analogue for prostate cancer imaging without biasing for differences in radiochemical approach"@en ; prodottidellaricerca:prodottoDi istituto:CDS035 , modulo:ID7888 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA11322 , unitaDiPersonaleInterno:MATRICOLA19901 . ns11:ID238851 pubblicazioni:rivistaDi prodotto:ID201954 .