@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS023 prodottidellaricerca:prodotto prodotto:ID198287 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA19166 pubblicazioni:autoreCNRDi prodotto:ID198287 . istituto:CDS031 prodottidellaricerca:prodotto prodotto:ID198287 . unitaDiPersonaleInterno:MATRICOLA9501 pubblicazioni:autoreCNRDi prodotto:ID198287 . @prefix modulo: . modulo:ID2380 prodottidellaricerca:prodotto prodotto:ID198287 . @prefix rdf: . @prefix retescientifica: . prodotto:ID198287 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID198287 rdfs:label "Zinc(II) complexes with dithiocarbamato derivatives: Structural characterisation and biological assays on cancerous cell lines (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID198287 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.jinorgbio.2012.09.004"^^xsd:string . @prefix skos: . prodotto:ID198287 skos:altLabel "
Nagy, E.M.a, Sitran, S.b, Montopoli, M.c, Favaro, M.b, Marchi\u00F2, L.d, Caparrotta, L.c, Fregona, D.a (2012)
Zinc(II) complexes with dithiocarbamato derivatives: Structural characterisation and biological assays on cancerous cell lines
in Journal of inorganic biochemistry
"^^rdf:HTML ; pubblicazioni:autori "Nagy, E.M.a, Sitran, S.b, Montopoli, M.c, Favaro, M.b, Marchi\u00F2, L.d, Caparrotta, L.c, Fregona, D.a"^^xsd:string ; pubblicazioni:paginaInizio "131"^^xsd:string ; pubblicazioni:paginaFine "139"^^xsd:string ; pubblicazioni:url "http://www.sciencedirect.com/science/article/pii/S0162013412002796"^^xsd:string ; pubblicazioni:numeroVolume "117"^^xsd:string . @prefix ns11: . prodotto:ID198287 pubblicazioni:rivista ns11:ID322717 ; skos:note "ISI Web of Science (WOS)"^^xsd:string , "Scopu"^^xsd:string ; pubblicazioni:affiliazioni "1,7 : Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131 Padova, Italy /\n2,4 : Institute of Inorganic and Surfaces Chemistry, C.N.R. Research Area, Corso Stati Uniti 4, 35127 Padova, Italy /\n3,6 : Department of Pharmacology and Anaesthesiology, University of Padova, L.go Meneghetti 2, 35131, Padova, Italy /\n5 : Department of General and Inorganic Chemistry, Analytical Chemistry, Physical Chemistry, University of Parma, V.le G.P. Usberti 17/A, 43100 Parma, Italy"^^xsd:string ; pubblicazioni:titolo "Zinc(II) complexes with dithiocarbamato derivatives: Structural characterisation and biological assays on cancerous cell lines"^^xsd:string ; prodottidellaricerca:abstract "Zinc is one of the most important trace elements in the body and it is essential as a cofactor for the structure and function of a number of cellular molecules including enzymes, transcription factors, cellular signalling proteins and DNA repair enzymes. On the other hand, recent studies have shown that zinc could play a role both in the development of various cancers and in the induction of apoptosis in some cell types, however, no established common relationships of zinc with cancer development and progression have been identified. To date, in our research group different metal-dithiocarbamato complexes have been designed that were expected to resemble the main features of cisplatin together with higher activity, improved selectivity and bioavailability, and lower side-effects. On the basis of the obtained encouraging achievements with other metals (such as gold and copper) we have decided to enlarge the studies to the complexes of zinc(II) using the same ligands. Hereby, we report the results on the synthesis and characterisation of ZnL2 complexes with five different dithiocarbamato derivatives, such as dimethyl-(DMDT), pyrrolidine-(PyDT), methyl-(MSDT), ethyl-(ESDT) and tert-butyl-(TSDT) sarcosinedithiocarbamate. All the obtained compounds have fully been characterised by means of several spectroscopic techniques. In addition, the crystal structure of [Zn(MSDT)(2)](2) dinuclear complex is also reported. In order to evaluate the in vitro cytotoxic properties, some biological assays have been carried out on a panel of human tumour cell lines sensible and resistant to cisplatin. Some of the tested compounds show cytotoxicity levels comparable or even greater than the reference drug (cisplatin)."@en ; prodottidellaricerca:prodottoDi istituto:CDS023 , modulo:ID2380 , istituto:CDS031 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19166 , unitaDiPersonaleInterno:MATRICOLA9501 . @prefix parolechiave: . prodotto:ID198287 parolechiave:insiemeDiParoleChiave . ns11:ID322717 pubblicazioni:rivistaDi prodotto:ID198287 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID198287 .