@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS053 prodottidellaricerca:prodotto prodotto:ID197722 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA6038 pubblicazioni:autoreCNRDi prodotto:ID197722 . @prefix modulo: . modulo:ID8646 prodottidellaricerca:prodotto prodotto:ID197722 . @prefix rdf: . prodotto:ID197722 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID197722 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID197722 rdfs:label "Analysis of venlafaxine by capillary zone electrophoresis (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID197722 pubblicazioni:anno "1997-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID197722 skos:altLabel "
FANALI S, COTICHINI V, PORRA R (1997)
Analysis of venlafaxine by capillary zone electrophoresis
in Journal of capillary electrophoresis
"^^rdf:HTML ; pubblicazioni:autori "FANALI S, COTICHINI V, PORRA R"^^xsd:string ; pubblicazioni:paginaInizio "21"^^xsd:string ; pubblicazioni:paginaFine "26"^^xsd:string ; pubblicazioni:numeroVolume "4"^^xsd:string . @prefix ns11: . prodotto:ID197722 pubblicazioni:rivista ns11:ID228086 ; skos:note "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "IMC-CNR; Istituto Superiore di Sanit\u00E0; Istituto Superiore di Sanit\u00E0;"^^xsd:string ; pubblicazioni:titolo "Analysis of venlafaxine by capillary zone electrophoresis"^^xsd:string ; prodottidellaricerca:abstract "Capillary electrophoresis has been used for the separation of venlafaxine and two of its impurities deriving from the synthesis process. The electrophoretic experiments were performed using background electrolytes at different pHs in the 2.5-9.2 range in order to study the effective mobilities and resolution of the three examined compounds. The optimum experimental conditions for the baseline resolution of the three analytes was found at pH 6.5. Very good repeatability for both migration time and corrected peak areas was achieved. The calibration curve was studied for venlafaxine (concentration range 26-224 micrograms/mL), and the plot of the peak area ratio (sample/internal standard [IS]) versus venlafaxine concentration was linear with a correlation coefficient of 0.9991. The effect of different cyclodextrins (CDs), namely, gamma-cyclodextrin (gamma-CD), hydroxypropyl-beta-CD (HP-beta-CD), and alpha-cyclodextrin (alpha-CD), on effective mobility and enantiomeric resolution (R) of venlafaxine (Wy45030) and its impurities (imp1 and imp2) was studied at different pHs, and the best results were obtained at pH 9.2. Venlafaxine was baseline resolved in its enantiomers using gamma-CD or HP-beta-CD, while imp1 (Wy45494) was baseline resolved using alpha-CD."@en ; prodottidellaricerca:prodottoDi istituto:CDS053 , modulo:ID8646 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA6038 . ns11:ID228086 pubblicazioni:rivistaDi prodotto:ID197722 .