@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA957 pubblicazioni:autoreCNRDi prodotto:ID196929 . @prefix prodottidellaricerca: . @prefix modulo: . modulo:ID8628 prodottidellaricerca:prodotto prodotto:ID196929 . @prefix rdf: . prodotto:ID196929 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID196929 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID196929 rdfs:label "The nerve growth factor administrated as eye drops activates mature and precursor cells in subventricular zone of adult rats (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID196929 pubblicazioni:anno "2011-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.4449/aib.v149i1.1359"^^xsd:string . @prefix skos: . prodotto:ID196929 skos:altLabel "
Paola Tirassa (2011)
The nerve growth factor administrated as eye drops activates mature and precursor cells in subventricular zone of adult rats
in Archives Italiennes de Biologie
"^^rdf:HTML ; pubblicazioni:autori "Paola Tirassa"^^xsd:string ; pubblicazioni:paginaInizio "205"^^xsd:string ; pubblicazioni:paginaFine "213"^^xsd:string ; pubblicazioni:numeroVolume "149"^^xsd:string . @prefix ns10: . prodotto:ID196929 pubblicazioni:rivista ns10:ID593384 ; pubblicazioni:numeroFascicolo "2"^^xsd:string ; pubblicazioni:affiliazioni "Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy (*)\n(*) Confluito in IBCN - Provv. del Presidente del CNR n. 000116 prot. 0091899 del 21/12/2010"^^xsd:string ; pubblicazioni:titolo "The nerve growth factor administrated as eye drops activates mature and precursor cells in subventricular zone of adult rats"^^xsd:string ; prodottidellaricerca:abstract "The possibility to take advantage from the nerve growth factor (NGF) ability to induce recovery of damaged tissue has been largely explored in animal models and humans. Recently, the successful use of the ocular administration of NGF in ophthalmology, and the evidences that from the eyes NGF can access to the brain have stimulated new fields of research and open further perspectives to the clinical application of this neurotrophin. In our previous studies we have demonstrated the efficacy of NGF eye drop treatment to improved behavioural deficits and recover structural and biochemical alterations occurring follow brain lesion in animals. Since NGF exerts neuroreparative effects in brain by acting on mature neurons and neuronal precursors localised in germinal subventricular zone (SVZ), the present study has been aimed to evaluate the effects of NGF eye drop administration on the expression of the mitotic marker Ki67 in brain of adult rats. We found that a single ocular administration (10 ?l) of 200 ?g/mL NGF solution is sufficient to enhance the distribution of Ki67 positive cells also expressing p75 neurotrophin receptors in the proliferating layer of the SVZ. In addition, NGF treatment induces an increase of levels of brain derived neurotrophic factor (BDNF) in forebrain. This data further supports the efficacy of ocular applied NGF to affect brain activities and suggests that NGF also by inducing local factors, including BDNF, can activate the machinery regulating the proliferation and maturation of neuronal precursor in brain." ; prodottidellaricerca:prodottoDi modulo:ID8628 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA957 . ns10:ID593384 pubblicazioni:rivistaDi prodotto:ID196929 .