@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS024 prodottidellaricerca:prodotto prodotto:ID19165 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA14170 pubblicazioni:autoreCNRDi prodotto:ID19165 . @prefix modulo: . modulo:ID7802 prodottidellaricerca:prodotto prodotto:ID19165 . @prefix rdf: . prodotto:ID19165 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID19165 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID19165 rdfs:label "Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID19165 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1038/oby.2008.297"^^xsd:string . @prefix skos: . prodotto:ID19165 skos:altLabel "
Mingrone, G 1; Manco, M 2; Iaconelli, A 1; Gniuli, D 1; Bracaglia, R 3; Leccesi, L 1; Calvani, M 1; Nolfe, G 4; Basus, S 5; Berria, R 5 (2008)
Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery
in Obesity (Silver Spring, Md.)
"^^rdf:HTML ; pubblicazioni:autori "Mingrone, G 1; Manco, M 2; Iaconelli, A 1; Gniuli, D 1; Bracaglia, R 3; Leccesi, L 1; Calvani, M 1; Nolfe, G 4; Basus, S 5; Berria, R 5"^^xsd:string ; pubblicazioni:paginaInizio "1831"^^xsd:string ; pubblicazioni:paginaFine "1837"^^xsd:string ; pubblicazioni:numeroVolume "16"^^xsd:string . @prefix ns11: . prodotto:ID19165 pubblicazioni:rivista ns11:ID113849 ; skos:note "PubMe"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. Univ Cattolica Sacro Cuore, Dept Internal Med, Rome, Italy\n2. Bambino Gesu Hosp & Res Inst, Liver Unit, Rome, Italy\n3. Univ Cattolica Sacro Cuore, Dept Surg, Rome, Italy\n4. CNR, Inst Cybernet E Caianiello, Pozzuoli, Italy\n5. Case Western Reserve Univ, Metrohlth Med Ctr, Dept Obstet & Gynecol, Cleveland, OH USA"^^xsd:string ; pubblicazioni:titolo "Prolactin and insulin ultradian secretion and adipose tissue lipoprotein lipase expression in severely obese women after bariatric surgery"^^xsd:string ; prodottidellaricerca:abstract "Background: Hyperprolactinemia is associated with obesity. Furthermore, in human adipose tissue cultured in vitro,\nprolactin (PRL) inhibited lipoprotein lipase (LPL) activity via functional PRL receptors.\nObjective: Tostudy PRL and insulin ultradian rhythm and subcutaneous adipose tissue LPL mRNA and protein\nexpressions in severely obese women before and after malabsorptive bariatric surgery.\nMethods and Procedures: Seven severely obese, fertile women were studied twice, once before and the second\ntime 1 year after bilio-pancreatic diversion (BPD), when the weight was stable for at least 3 months. Metabolizable\nenergy intake and 24-h energy expenditure (EE) were measured. Fourier and PULSEFIT analyses were applied to\n24-h hormonal time-series to study daily fluctuations and hormonal clearance. Insulin sensitivity was assessed by\neuglycemic-hyperinsulinemic clamp. Quantitative-competitive reverse transcriptase-PCR and western blot analysis\nwere used to measure LPL gene expression.\nResults: Spontaneous 24-h PRL secretion was significantly reduced after BPD (mean-daily release, 128.4 \u00B1 28.1 ?g/l\nvs. 67.2 \u00B1 9.2 ?g/l distribution volume (Vd/l\u00B724 h), P = 0.02); insulin secretion also was significantly reduced (499.9 \u00B1\n204.0 ?g/Vd/l\u00B724 h vs. 85.6 \u00B1 21.0 ?g/Vd/l\u00B724 h, P = 0.0001). Metabolizable energy/kgFFM did not change significantly\nafter BPD. Twenty-four-hour EE, but not 24-h EE/FFM, was significantly decreased after BPD (P < 0.05). Insulin\nsensitivity significantly (P < 0.0001) increased after BPD from 21.41 \u00B1 1.92 to 68.62 \u00B1 5.03 ?mol/kgFFM/min. LPL mRNA\nconcentration (from 42.63 \u00B1 4.21% to 19.00 \u00B1 2.74% of cyclophilin mRNA, P = 0.001) as well as LPL protein level (from\n8.94 \u00B1 2.73 to 3.16 \u00B1 1.05 as ratios of protein of interest vs. housekeeping protein, P = 0.038) significantly decreased\nafter BPD. The major determinant of PRL secretion was insulin secretion, whereas the best predictors of LPL\nexpression were insulin and PRL secretion rates.\nDiscussion: The restriction of lipid metabolizable energy rather than weight loss seems to be responsible for both\nreduction in PRL circulating levels and normalization of its secretion rhythm after bariatric surgery. Furthermore, the\nreduced adipose tissue LPL expression, being significantly correlated with the decrease in insulin and PRL, suggests a\nrole of hyperinsulinemia and hyperprolactinemia in inducing and sustaining obesity."@en ; prodottidellaricerca:prodottoDi modulo:ID7802 , istituto:CDS024 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA14170 . @prefix parolechiave: . prodotto:ID19165 parolechiave:insiemeDiParoleChiave . ns11:ID113849 pubblicazioni:rivistaDi prodotto:ID19165 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID19165 .