@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA9225 pubblicazioni:autoreCNRDi prodotto:ID191561 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID191561 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID2085 pubblicazioni:autoreCNRDi prodotto:ID191561 . unitaDiPersonaleInterno:MATRICOLA14458 pubblicazioni:autoreCNRDi prodotto:ID191561 . @prefix modulo: . modulo:ID2650 prodottidellaricerca:prodotto prodotto:ID191561 . @prefix rdf: . @prefix retescientifica: . prodotto:ID191561 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID191561 rdfs:label "Long-term administration with levonorgestrel decreases allopregnanolone levels, alters GABAA receptor subunit expression and anxiety-like behavior. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID191561 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.pbb.2012.05.011"^^xsd:string . @prefix skos: . prodotto:ID191561 skos:altLabel "
Porcu P., Mostallino M.C., Sogliano C., Santoru F., Berretti R., Concas A (2012)
Long-term administration with levonorgestrel decreases allopregnanolone levels, alters GABAA receptor subunit expression and anxiety-like behavior.
in Pharmacology, biochemistry and behavior
"^^rdf:HTML ; pubblicazioni:autori "Porcu P., Mostallino M.C., Sogliano C., Santoru F., Berretti R., Concas A"^^xsd:string ; pubblicazioni:paginaInizio "366"^^xsd:string ; pubblicazioni:paginaFine "372"^^xsd:string ; pubblicazioni:url "http://www.sciencedirect.com/science/article/pii/S0091305712001463"^^xsd:string ; pubblicazioni:numeroVolume "102"^^xsd:string . @prefix ns12: . prodotto:ID191561 pubblicazioni:rivista ns12:ID306889 ; pubblicazioni:numeroFascicolo "2"^^xsd:string ; skos:note "PubMe"^^xsd:string ; pubblicazioni:affiliazioni "CNR National Research Council of Italy, Institute of Neuroscience, Cagliari; University of Cagliari"^^xsd:string ; pubblicazioni:titolo "Long-term administration with levonorgestrel decreases allopregnanolone levels, alters GABAA receptor subunit expression and anxiety-like behavior."^^xsd:string ; prodottidellaricerca:abstract "Fluctuations in the concentrations of the neuroactive steroid allopregnanolone are thought to influence ?-amino-butyric acid type A (GABA(A)) receptor gene expression and function. Long-term treatment with ethinyl estradiol (EE) plus levonorgestrel (LNG), two of the most widely used steroids in the hormonal contraceptive pill, decreases allopregnanolone levels in rat cerebral cortex and plasma, alters GABA(A) receptor expression and induces anxiety-like behavior. We evaluated which component of the hormonal contraceptive pill is responsible for the aforementioned changes. Female rats were injected subcutaneously (s.c.) with EE (0.030 mg) or LNG (0.125 mg) once a day for 4 weeks. Compared to the respective vehicle-treated control groups, EE decreased cerebral cortical levels of allopregnanolone, progesterone and pregnenolone by 76, 72 and 33%, respectively and hippocampal levels by 52, 56 and 50%, respectively. Likewise, LNG decreased cerebral cortical levels of allopregnanolone, progesterone and pregnenolone by 75, 68 and 33%, respectively, and hippocampal levels by 55, 65 and 60%, respectively. Administration of LNG, but not EE, increased the abundance of the ?2 subunit peptide in cerebral cortex and hippocampus by 38 and 59%, respectively. Further, LNG, but not EE, decreased the time spent and the number of entries into the open arms of the elevated plus maze by 56 and 43%, respectively, an index of anxiety-like behavior. These results suggest that alterations in GABA(A) receptor subunit expression and anxiety-like behavior induced by long-term treatment with combined EE/LNG appear to be caused by LNG. Given that both EE and LNG decrease allopregnanolone levels in a similar manner, these results further suggest that changes in allopregnanolone levels are not associated with GABA(A) receptor expression."@en ; prodottidellaricerca:prodottoDi istituto:CDS061 , modulo:ID2650 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9225 , unitaDiPersonaleEsterno:ID2085 , unitaDiPersonaleInterno:MATRICOLA14458 . @prefix parolechiave: . prodotto:ID191561 parolechiave:insiemeDiParoleChiave . ns12:ID306889 pubblicazioni:rivistaDi prodotto:ID191561 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID191561 .