@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA29473 pubblicazioni:autoreCNRDi prodotto:ID191313 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID1219 pubblicazioni:autoreCNRDi prodotto:ID191313 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID191313 . unitaDiPersonaleEsterno:ID8729 pubblicazioni:autoreCNRDi prodotto:ID191313 . unitaDiPersonaleEsterno:ID15619 pubblicazioni:autoreCNRDi prodotto:ID191313 . unitaDiPersonaleInterno:MATRICOLA14889 pubblicazioni:autoreCNRDi prodotto:ID191313 . @prefix modulo: . modulo:ID2650 prodottidellaricerca:prodotto prodotto:ID191313 . unitaDiPersonaleInterno:MATRICOLA14782 pubblicazioni:autoreCNRDi prodotto:ID191313 . @prefix rdf: . @prefix retescientifica: . prodotto:ID191313 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID191313 rdfs:label "Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID191313 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1111/j.1530-0277.2012.01782.x"^^xsd:string . @prefix skos: . prodotto:ID191313 skos:altLabel "
Maccioni P., Zaru A., Loi B., Lobina C., Carai M.A.M., Gessa G.L., Capra A., Mugnaini C., Pasquini S., Corelli F., Hyyti\u00E4 P., Lumeng L., Colombo G. (2012)
Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats
in Alcoholism, clinical and experimental research
"^^rdf:HTML ; pubblicazioni:autori "Maccioni P., Zaru A., Loi B., Lobina C., Carai M.A.M., Gessa G.L., Capra A., Mugnaini C., Pasquini S., Corelli F., Hyyti\u00E4 P., Lumeng L., Colombo G."^^xsd:string ; pubblicazioni:paginaInizio "1748"^^xsd:string ; pubblicazioni:paginaFine "1766"^^xsd:string ; pubblicazioni:numeroVolume "36"^^xsd:string . @prefix ns12: . prodotto:ID191313 pubblicazioni:rivista ns12:ID316082 ; pubblicazioni:pagineTotali "19"^^xsd:string ; pubblicazioni:numeroFascicolo "10"^^xsd:string ; pubblicazioni:affiliazioni "Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA), Italy; Department of Life and Environmental Sciences, University of Cagliari, Cagliari (CA), Italy; Department of Pharmaceutical and Applied Chemistry, University of Siena, Siena (SI), Italy; Department of Biomedicine/Pharmacology, University of Helsinki, Helsinki, Finland; Department of Medicine, Indiana University, Indianapolis, IN, USA."^^xsd:string ; pubblicazioni:titolo "Comparison of the effect of the GABAB receptor agonist, baclofen, and the positive allosteric modulator of the GABAB receptor, GS39783, on alcohol self-administration in three different lines of alcohol-preferring rats"^^xsd:string ; prodottidellaricerca:abstract "Background: Administration of the GABAB receptor agonist, baclofen, and positive allosteric modulator (PAM), GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. The present study was designed to compare the effect of baclofen and GS39783 on alcohol self-administration in three lines of selectively bred, alcohol-preferring rats: Indiana alcohol-preferring (P), Sardinian alcohol-preferring (sP), and Alko Alcohol (AA). Methods: Rats of each line were initially trained to respond on a lever, on a fixed ratio (FR) 4 (FR4) schedule of reinforcement, to orally self-administer alcohol (15%, v/v) in daily 30-min sessions. Once responding reached stable levels, rats were exposed to a sequence of experiments testing baclofen (0, 1, 1.7, and 3 mg/kg; i.p.) and GS39783 (0, 25, 50, and 100 mg/kg; i.g.) on FR4 and progressive ratio (PR) schedules of reinforcement. Finally, to assess the specificity of baclofen and GS39783 action, rats were slightly food-deprived and trained to lever-respond for food pellets. Results: The rank of order of the reinforcing and motivational properties of alcohol was: P>sP>AA rats. Under both FR and PR schedules of reinforcement, the rank of order of potency and efficacy of baclofen and GS39783 in suppressing alcohol self-administration was: P>sP>AA rats. Only the highest dose of baclofen reduced lever-responding for food pellets; this effect was common to all three rat lines. Conversely, no dose of GS39783 altered lever-responding for food in any rat line. Conclusions: These results suggest that: (a) the strength of the reinforcing and motivational properties of alcohol differ among P, sP, and AA rats; (b) the reinforcing and motivational properties of alcohol in P, sP, and AA rats are differentially sensitive to treatment with baclofen and GS39783; (c) the heterogeneity in sensitivity to baclofen and GS39783 of alcohol self-administration in P, sP, and AA rats may resemble the differential effectiveness of pharmacotherapies among the different typologies of human alcoholics; (d) the GABAB receptor is part of the neural substrate mediating the reinforcing and motivational properties of alcohol."@en ; prodottidellaricerca:prodottoDi istituto:CDS061 , modulo:ID2650 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA14889 , unitaDiPersonaleEsterno:ID15619 , unitaDiPersonaleEsterno:ID8729 , unitaDiPersonaleEsterno:ID1219 , unitaDiPersonaleInterno:MATRICOLA29473 , unitaDiPersonaleInterno:MATRICOLA14782 . @prefix parolechiave: . prodotto:ID191313 parolechiave:insiemeDiParoleChiave . ns12:ID316082 pubblicazioni:rivistaDi prodotto:ID191313 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID191313 .