@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS009 prodottidellaricerca:prodotto prodotto:ID190451 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA5183 pubblicazioni:autoreCNRDi prodotto:ID190451 . unitaDiPersonaleInterno:MATRICOLA7391 pubblicazioni:autoreCNRDi prodotto:ID190451 . @prefix modulo: . modulo:ID7740 prodottidellaricerca:prodotto prodotto:ID190451 . unitaDiPersonaleInterno:MATRICOLA12890 pubblicazioni:autoreCNRDi prodotto:ID190451 . @prefix rdf: . prodotto:ID190451 rdf:type prodotto:TIPO1105 . @prefix retescientifica: . prodotto:ID190451 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID190451 rdfs:label "Integration of quantitative biomarkers from in vivo multi-modal PET and MR studies for the diagnostic and therapeutic management of Gastric Cancer patients (Abstract in rivista)"@en . @prefix xsd: . prodotto:ID190451 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID190451 skos:altLabel "
Carla Canevari; Francesca Gallivanone; F. De Cobelli; F. Giganti; E. Orsenigo; L. Albarello; A. Del Maschio; Maria Carla Gilardi; Isabella Castiglioni; Luigi Gianolli. (2012)
Integration of quantitative biomarkers from in vivo multi-modal PET and MR studies for the diagnostic and therapeutic management of Gastric Cancer patients
"^^rdf:HTML ; pubblicazioni:autori "Carla Canevari; Francesca Gallivanone; F. De Cobelli; F. Giganti; E. Orsenigo; L. Albarello; A. Del Maschio; Maria Carla Gilardi; Isabella Castiglioni; Luigi Gianolli."^^xsd:string ; pubblicazioni:paginaInizio "S370"^^xsd:string ; pubblicazioni:numeroVolume "39"^^xsd:string . @prefix ns11: . prodotto:ID190451 pubblicazioni:rivista ns11:ID69266 ; pubblicazioni:numeroFascicolo "Suppl-2"^^xsd:string ; pubblicazioni:affiliazioni "San Raffaele Hospital, Milano. IBFM-CNR, Segrate (MI)."^^xsd:string ; pubblicazioni:titolo "Integration of quantitative biomarkers from in vivo multi-modal PET and MR studies for the diagnostic and therapeutic management of Gastric Cancer patients"^^xsd:string ; prodottidellaricerca:abstract "AIM: To evaluate the value of an integrated approach in the management of Gastric Cancer (GC) patients by means of quantitative biomarkers from multimodal 18F-FDG PET and Diffusion Weighted MR (MR-DWI) studies. MATERIALS AND METHODS: 17 patients affected by GC (3 in oesophageous, 3 in gastroesophageous- junction and 11 in gastric cancer) were enrolled and studied by a multimodal PET-MR quantitative approach. Patients performed: 18F-FDG PET/CT basal study (PET-I) (1mCi/10kg, 45 min from radiotracer injection), MR -DWI basal study (DWI-I) (1.5-T MR system, SSEPI sequence, b=600s/mm2), neo-adjuvant chemotherapy (NC), 18F-FDG PET/CT follow up study (PET-II), MR DWI follow up study (DWI-II), radical surgery with histopathological analysis. For each detected GC lesion, Partial Volume Corrected Body-Weight Standardized Uptake Value (PVC-SUVBW) was estimated from both PET-I and PET-II and Apparent Diffusion Coefficient (ADC) from both DWI-I and DWI-II. pT classification (infiltrating, non infiltrating), histological type (signet ring cell carcinoma, adenocarcinoma subtype and squamous cell carcinoma), and Tumor Regression Grade (TRG) were determined from histopathological analysis. By using statistical tests (Mann Whitney and Kruskal Wallis tests), PVC-SUVBW and ADC were correlated with histopathological findings, ?PVC-SUVBW and ?ADC with TRG. RESULTS: PVC-SUVBW was found significantly different in infiltrating vs non infiltrating pathologies (8.1\u00B16.2 g/cc vs 3.1\u00B11.0g/cc; p<0.05), and in signet ring cell, adenocarcinoma and squamous cell histological types (5.57\u00B13.22 g/cc vs 9.32 \u00B1 4.26g/cc vs 9.90 \u00B1 1.91g/cc; p=0.05). No significant correlations were found between ?PVC-SUVBW and TRG. ADC changes was found significantly different in responder patients (TRG = 1-3) vs non responder patients (TRG = 4-5) (106\u00B179% vs -8\u00B122%; p<0.01). No significant correlations were found with different infiltration characteristics and with different histological types. CONCLUSIONS: PVC-SUVBW can be considered a diagnostic biomarker in GC, allowing to define in vivo and non-invasively the infiltration level. ADC can be considered a biomarker predictive of therapeutic response to NC in GC, allowing to stratify responder and non responder patients. Our preliminary results suggest the combination of multi-modal PET and MR-DWI studies as a powerful approach for the diagnostic and therapeutic management of GC patients, opening the use of hybrid PET/MR systems to these pathologies."@en ; prodottidellaricerca:prodottoDi modulo:ID7740 , istituto:CDS009 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA12890 , unitaDiPersonaleInterno:MATRICOLA5183 , unitaDiPersonaleInterno:MATRICOLA7391 . ns11:ID69266 pubblicazioni:rivistaDi prodotto:ID190451 .