@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA5371 pubblicazioni:autoreCNRDi prodotto:ID188450 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS021 prodottidellaricerca:prodotto prodotto:ID188450 . @prefix modulo: . modulo:ID4226 prodottidellaricerca:prodotto prodotto:ID188450 . @prefix rdf: . @prefix retescientifica: . prodotto:ID188450 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID188450 rdfs:label "DAG1, no gene for RNA regulation? (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID188450 pubblicazioni:anno "2012-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.gene.2012.01.046"^^xsd:string . @prefix skos: . prodotto:ID188450 skos:altLabel "
Brancaccio, Andrea (2012)
DAG1, no gene for RNA regulation?
in Gene (Amst.)
"^^rdf:HTML ; pubblicazioni:autori "Brancaccio, Andrea"^^xsd:string ; pubblicazioni:paginaInizio "79"^^xsd:string ; pubblicazioni:paginaFine "82"^^xsd:string ; pubblicazioni:numeroVolume "497"^^xsd:string . @prefix ns11: . prodotto:ID188450 pubblicazioni:rivista ns11:ID350563 ; pubblicazioni:pagineTotali "4"^^xsd:string ; pubblicazioni:numeroFascicolo "1"^^xsd:string ; skos:note "ISI Web of Science (WoS)"^^xsd:string ; pubblicazioni:affiliazioni "Catholic University of the Sacred Heart"^^xsd:string ; pubblicazioni:titolo "DAG1, no gene for RNA regulation?"^^xsd:string ; prodottidellaricerca:abstract "DAG1 encodes for a precursor protein that liberates the two subunits featured by the dystroglycan (DG) adhesion complex that are involved in an increasing number of cellular functions in a wide variety of cells and tissues. Aside from the proteolytic events producing the alpha and beta subunits, especially the former undergoes extensive \\\"post-production\\\" modifications taking place within the ER/Golgi where its core protein is both N- and O-decorated with sugars. These post-translational events, that are mainly orchestrated by a plethora of certified, or putative, glycosyltransferases, prelude to the excocytosis-mediated trafficking and targeting of the DG complex to the plasma membrane. Extensive genetic and biochemical evidences have been accumulated so far on alpha-DG glycosylation, while little is know on possible regulatory events underlying the chromatine activation, transcription or post-transcription (splicing and escape from the nucleus) of DAG1 or of its mRNA. A scenario is envisaged in which cells would use a sort of preferential, and scarcely regulated, route for DAG1 activation, that would imply fast mRNA transcription, maturation and export to the cytosol, and would prelude to the multiple time-consuming enzymatic post-translational activities needed for its glycosylation. Such a provocative view might be helpful to trigger future work aiming at disclosing the complete molecular mechanisms underlying DAG1 activation and at improving our knowledge of any pre-translational step that is involved in dystroglycan regulation. (C) 2012 Elsevier B.V. All rights reserved." ; prodottidellaricerca:prodottoDi istituto:CDS021 , modulo:ID4226 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA5371 . @prefix parolechiave: . prodotto:ID188450 parolechiave:insiemeDiParoleChiave . ns11:ID350563 pubblicazioni:rivistaDi prodotto:ID188450 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID188450 .