@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS023 prodottidellaricerca:prodotto prodotto:ID18501 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA19166 pubblicazioni:autoreCNRDi prodotto:ID18501 . @prefix modulo: . modulo:ID4239 prodottidellaricerca:prodotto prodotto:ID18501 . @prefix rdf: . @prefix retescientifica: . prodotto:ID18501 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID18501 rdfs:label "Chemical and Biological Profiles of Novel Copper(II) Complexes Containing S-Donor Ligands for the Treatment of Cancer (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID18501 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID18501 skos:altLabel "
Giovagnini L. 1,Sitran S. 2 ,Montopoli M. 3,Caparrotta L. 3, Corsini M. 4, Rosani C. 4,| Zanello P. 4, Q. Ping Dou 5, Fregona D. 1 (2008)
Chemical and Biological Profiles of Novel Copper(II) Complexes Containing S-Donor Ligands for the Treatment of Cancer
in Inorganic chemistry
"^^rdf:HTML ; pubblicazioni:autori "Giovagnini L. 1,Sitran S. 2 ,Montopoli M. 3,Caparrotta L. 3, Corsini M. 4, Rosani C. 4,| Zanello P. 4, Q. Ping Dou 5, Fregona D. 1"^^xsd:string ; pubblicazioni:paginaInizio "6336"^^xsd:string ; pubblicazioni:paginaFine "6343"^^xsd:string ; pubblicazioni:numeroVolume "47"^^xsd:string . @prefix ns11: . prodotto:ID18501 pubblicazioni:rivista ns11:ID394632 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. Department of Chemical Sciences, University of Padova, \n2. Institute of Inorganic and Surfaces Chemistry, CNR, Padova\n3. Department of Pharmacology and Anaesthesiology, University of Padova,\n4. Department of Chemistry, UniVersity of Siena, \n5. Barbara Ann Karmanos Cancer Institute and Department of Pathology,\nSchool of Medicine, Wayne State University"^^xsd:string ; pubblicazioni:titolo "Chemical and Biological Profiles of Novel Copper(II) Complexes Containing S-Donor Ligands for the Treatment of Cancer"^^xsd:string ; prodottidellaricerca:abstract "In the last years, we have synthesized some new platinum(II), palladium(II), gold(I/III) complexes with dithiocarbamato derivatives as potential anticancer drugs, to obtain compounds with superior chemotherapeutic index in terms of increased bioavailability, higher cytotoxicity, and lower side effects than cisplatin. On the basis of the obtained encouraging results, we have been studying the interaction of CuCl2 with methyl-/ethyl-/tert-butylsarcosinedithiocarbamato moieties in a 1:2 molar ratio; we also synthesized and studied the N,N-dimethyl- and pyrrolidinedithiocarbamato copper complexes for comparison purposes. The reported compounds have been successfully isolated, purified, and fully characterized by means of several spectroscopic techniques. Moreover, the electrochemical properties of the designed compounds have been studied through cyclic voltammetry. In addition, the behavior in solution was followed by means of UV-vis technique to check the stability with time in physiological conditions.\nTo evaluate their in vitro cytotoxic properties, preliminary biological assays (MTT test) have been carried out on a panel of human tumor cell lines. The results show that cytotoxicity levels of all of the tested complexes are comparable or even greater than that of the reference drug (cisplatin)." ; prodottidellaricerca:prodottoDi modulo:ID4239 , istituto:CDS023 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA19166 . @prefix parolechiave: . prodotto:ID18501 parolechiave:insiemeDiParoleChiave . ns11:ID394632 pubblicazioni:rivistaDi prodotto:ID18501 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID18501 .