@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA8257 pubblicazioni:autoreCNRDi prodotto:ID184335 . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID2476 pubblicazioni:autoreCNRDi prodotto:ID184335 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID184335 . unitaDiPersonaleInterno:MATRICOLA9188 pubblicazioni:autoreCNRDi prodotto:ID184335 . unitaDiPersonaleEsterno:ID2651 pubblicazioni:autoreCNRDi prodotto:ID184335 . unitaDiPersonaleEsterno:ID19480 pubblicazioni:autoreCNRDi prodotto:ID184335 . @prefix rdf: . @prefix retescientifica: . prodotto:ID184335 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID184335 rdfs:label "Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID184335 pubblicazioni:anno "2008-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID184335 skos:altLabel "
Pulcrano M; Camera L; Pagano L; Del Vecchio S; Ferone D; Bodei L; Murgia A; Pace L; Storto G; Paganelli G; Colao A; Salvatore M; Lombardi G; Biondi B. (2008)
Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease.
in Journal of endocrinological investigation (Online)
"^^rdf:HTML ; pubblicazioni:autori "Pulcrano M; Camera L; Pagano L; Del Vecchio S; Ferone D; Bodei L; Murgia A; Pace L; Storto G; Paganelli G; Colao A; Salvatore M; Lombardi G; Biondi B."^^xsd:string ; pubblicazioni:paginaInizio "352"^^xsd:string ; pubblicazioni:paginaFine "359"^^xsd:string ; pubblicazioni:numeroVolume "31"^^xsd:string . @prefix ns11: . prodotto:ID184335 pubblicazioni:rivista ns11:ID184633 ; pubblicazioni:pagineTotali "8"^^xsd:string ; pubblicazioni:affiliazioni "Department of Clinical and Molecular Endocrinology and Oncology and Department of Biomorphological and Functional Sciences - University \\\"Federico II\\\" - Naples - Department of Endocrinological and Metabolic Sciences - University of Genoa - Department of Nuclear Medicine - European Insititute of Oncology - Milan - Department of Endocrinology and Medical and Surgical Sciences - Padua Medical School - ITALY"^^xsd:string ; pubblicazioni:titolo "Usefulness of [111In-DTPA0] octreotide scintigraphy in a family with von Hippel-Lindau disease."^^xsd:string ; prodottidellaricerca:abstract "The identification of patients with von Hippel-Lindau (VHL) disease dictates accurate genetic counseling of family members, whereas screening for early detection of visceral and neurological involvement is usually performed by a combination of radiological and nuclear medicine techniques such as ultrasonography or contrast-enhanced computed tomography of the upper abdomen, magnetic resonance imaging of the central nervous system and 131I-metaiodobenzylguanidine-scintigraphy. The role of 111-indium-diethylenetriaminepentaacetic acid [111In-DTPA0] octreotide scintigraphy in this clinical context has never been investigated. Here, we report imaging findings in a VHL patient and in 3 consecutive family members undergoing clinical and radiological screening that included [111In-DTPA0] octreotide scintigraphy in addition to the above-mentioned procedures. Somatostatin receptor expression was investigated in vitro by immunohistochemistry in pancreatic tumor sections. On the basis of in vivo and in vitro findings, octreotide long-acting release treatment followed by 90Y-1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA0)-Tyr3-octreotide led to a lack of progression in this patient although this result is a possibility which needs to be proved by further investigation and longer follow-up. The results of this study suggest that [111In-DTPA0] octreotide scintigraphy may be helpful in the routine work-up of VHL patients for diagnostic and therapeutic purposes."@en ; prodottidellaricerca:prodottoDi istituto:CDS017 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID19480 , unitaDiPersonaleEsterno:ID2476 , unitaDiPersonaleInterno:MATRICOLA9188 , unitaDiPersonaleInterno:MATRICOLA8257 , unitaDiPersonaleEsterno:ID2651 . ns11:ID184633 pubblicazioni:rivistaDi prodotto:ID184335 .