@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS061 prodottidellaricerca:prodotto prodotto:ID180772 . @prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . unitaDiPersonaleEsterno:ID7273 pubblicazioni:autoreCNRDi prodotto:ID180772 . @prefix modulo: . modulo:ID6440 prodottidellaricerca:prodotto prodotto:ID180772 . @prefix rdf: . prodotto:ID180772 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID180772 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID180772 rdfs:label "Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID180772 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1111/j.1532-5415.2006.00798.x"^^xsd:string . @prefix skos: . prodotto:ID180772 skos:altLabel "
Pantoni L; Poggesi A; Basile AM; Pracucci G; Barkhof F; Chabriat H; Erkinjuntti T; Ferro JM; Hennerici M; O'Brien J; Schmidt R; Visser MC; Wahlund LO; Waldemar G; Wallin A; Inzitari D; LADIS Study Group. (2006)
Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study.
in Journal of the American Geriatrics Society
"^^rdf:HTML ; pubblicazioni:autori "Pantoni L; Poggesi A; Basile AM; Pracucci G; Barkhof F; Chabriat H; Erkinjuntti T; Ferro JM; Hennerici M; O'Brien J; Schmidt R; Visser MC; Wahlund LO; Waldemar G; Wallin A; Inzitari D; LADIS Study Group."^^xsd:string ; pubblicazioni:paginaInizio "1095"^^xsd:string ; pubblicazioni:paginaFine "1101"^^xsd:string ; pubblicazioni:url "http://onlinelibrary.wiley.com/doi/10.1111/j.1532-5415.2006.00798.x/pdf"^^xsd:string ; pubblicazioni:numeroVolume "54"^^xsd:string . @prefix ns11: . prodotto:ID180772 pubblicazioni:rivista ns11:ID292919 ; pubblicazioni:pagineTotali "7"^^xsd:string ; pubblicazioni:numeroFascicolo "7"^^xsd:string ; skos:note "PubMe"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy; Department of Neurology, VU Medical Center, Amsterdam, the Netherlands; \nDepartment of Neurology, Hopital Lariboisiere, Paris, France; \nMemory Research Unit, Department of Clinical Neurosciences, Helsinki University, Helsinki, Finland; \nDepartment of Neurology, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal; \nDepartment of Neurology, University of Heidelberg, Klinikum Mannheim,Mannheim, Germany; Institute for Aging and Health, University of Newcastle, Newcastle-upon-Tyne, United Kingdom;\nDepartment of Neurology and MRI Institute, Medical University Graz, Austria; \nKarolinska Institute, Department of Clinical Neuroscience and Family Medicine, Huddinge University Hospital, Huddinge, Sweden;\nMemory Disorders Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark; \nInstitute of Clinical Neuroscience, Goteborg University, Goteborg, Sweden."^^xsd:string ; pubblicazioni:titolo "Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study."^^xsd:string ; prodottidellaricerca:abstract "DESIGN: Cross-sectional data analysis from an ongoing longitudinal multicenter and multinational study. \nSETTING: The Leukoaraiosis and Disability Study, a collaboration aimed at assessing leukoaraiosis as an independent predictor of the transition to disability in older people. \nPARTICIPANTS: Six hundred thirty-nine nondisabled subjects (288 men, 351 women, mean age standard deviation 74.1 +/- 5.0) with magnetic resonance imaging-detected leukoaraiosis of different severity and presenting with one of the following: mild cognitive or motor disturbances, minor cerebrovascular events, or mood alterations or in whom leukoaraiosis was incidentally identified. \nMEASUREMENTS: Centralized assessment of leukoaraiosis severity according to the three severity degrees of the Fazekas scale; Disability Assessment for Dementia (DAD) Scale for measurement of global functioning. \nRESULTS: At baseline, 44% of participants had a mild, 31% a moderate, and 25% a severe degree of leukoaraiosis. A significant trend toward declining performance on the DAD Scale was apparent with increasing leukoaraiosis score severity (total score = 98.8, 98.6, 97.5, respectively, in the three leukoaraiosis categories, analysis of variance P = .002). Similar trends were obtained for basic (P = .01) and instrumental (P < .001) function items. The statistical significance of these differences was confirmed in a multiple linear regression analysis correcting for numerous factors known to influence disability in older people. Executive function test performance declined along with increasing leukoaraiosis severity and was significantly related to DAD total score. \nCONCLUSION: Even in nondisabled elderly patients, levels of functional ability are related to white matter lesion severity. Executive dysfunction may mediate this relationship."@en ; prodottidellaricerca:prodottoDi istituto:CDS061 , modulo:ID6440 ; pubblicazioni:autoreCNR unitaDiPersonaleEsterno:ID7273 . @prefix parolechiave: . prodotto:ID180772 parolechiave:insiemeDiParoleChiave . ns11:ID292919 pubblicazioni:rivistaDi prodotto:ID180772 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID180772 .