@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS045 prodottidellaricerca:prodotto prodotto:ID180339 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA16929 pubblicazioni:autoreCNRDi prodotto:ID180339 . unitaDiPersonaleInterno:MATRICOLA6729 pubblicazioni:autoreCNRDi prodotto:ID180339 . @prefix modulo: . modulo:ID2507 prodottidellaricerca:prodotto prodotto:ID180339 . @prefix rdf: . prodotto:ID180339 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID180339 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID180339 rdfs:label "Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID180339 pubblicazioni:anno "2010-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.2337/dc09-1237"^^xsd:string . @prefix skos: . prodotto:ID180339 skos:altLabel "
Winhofer Y; Handisurya A; Tura A; Bittighofer C; Klein K; Schneider B; Bieglmayer C; Wagner OF; Pacini G; Luger A; Kautzky-Willer A (2010)
Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus
in Diabetes care
"^^rdf:HTML ; pubblicazioni:autori "Winhofer Y; Handisurya A; Tura A; Bittighofer C; Klein K; Schneider B; Bieglmayer C; Wagner OF; Pacini G; Luger A; Kautzky-Willer A"^^xsd:string ; pubblicazioni:paginaInizio "139"^^xsd:string ; pubblicazioni:paginaFine "143"^^xsd:string ; pubblicazioni:numeroVolume "33"^^xsd:string . @prefix ns11: . prodotto:ID180339 pubblicazioni:rivista ns11:ID318181 ; pubblicazioni:numeroFascicolo "1"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1, 2, 4, 10, 11: Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria\n3, 9: Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy\n5: Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria\n6: Institute of Medical Statistics, Medical University of Vienna, Vienna, Austria\n7, 8: Clinical Institute for Medical and Chemical Laboratory Diagnostic, General Hospital of Vienna, Vienna, Austria"^^xsd:string ; pubblicazioni:titolo "Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus"^^xsd:string ; prodottidellaricerca:abstract "OBJECTIVE-- There is growing evidence that osteocalcin, an osteoblast-derived protein\nlocally acting on bone formation, can increase insulin secretion as well as insulin sensitivity and\nthus prevent the development of obesity and diabetes in experimental animals. In humans,\nosteocalcin has been reported to be decreased in patients with type 2 diabetes. Because gestational\ndiabetes mellitus (GDM) can serve as a model of pre-type 2 diabetes, the aim of this study\nwas to investigate osteocalcin in GDM.\nRESEARCH DESIGN AND METHODS-- Osteocalcin measurement and an oral glucose\ntolerance test were performed in 78 pregnant women (26 women had GDM and 52 women\nhad normal glucose tolerance [NGT] during pregnancy; women were matched for age and BMI)\nand in 34 women postpartum.\nRESULTS-- During pregnancy osteocalcin was significantly higher in the women with GDM\nthan in the women with NGT (15.6 \u00B1 6.4 vs. 12.6 \u00B1 4.0 ng/ml; P < 0.015), whereas no\ndifference was observed between the two groups at 12 weeks postpartum (36.2 \u00B1 10.2 vs.\n36.2 \u00B1 13.0 ng/ml), when osteocalcin was found to be increased compared with the level in the\npregnant state in all women (+145 \u00B1 102% in GDM vs. +187 \u00B1 119% in NGT; P < 0.0001).\nMoreover, osteocalcin showed a significant correlation with basal and total insulin secretion in\nthe whole study group (R = 0.3, P < 0.01).\nCONCLUSIONS-- In GDM osteocalcin was higher and thus less restrained than in women\nwith NGT during pregnancy and furthermore correlated with insulin secretion parameters.\nTherefore, it could be hypothesized that osteocalcin can enhance insulin secretion in insulinresistant\nstates; alternatively an effect of hyperinsulinemia on osteocalcin secretion cannot be\nexcluded."@en ; prodottidellaricerca:prodottoDi istituto:CDS045 , modulo:ID2507 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA16929 , unitaDiPersonaleInterno:MATRICOLA6729 . ns11:ID318181 pubblicazioni:rivistaDi prodotto:ID180339 .