@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID169328 . @prefix modulo: . modulo:ID2653 prodottidellaricerca:prodotto prodotto:ID169328 . @prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA5731 pubblicazioni:autoreCNRDi prodotto:ID169328 . @prefix rdf: . prodotto:ID169328 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID169328 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID169328 rdfs:label "Fetal cells in maternal blood: a six-fold increase in women who have undergone amniocentesis and carry a fetus with Down syndrome: a multicenter study (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID169328 pubblicazioni:anno "2004-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1055/s-2004-830365"^^xsd:string . @prefix skos: . prodotto:ID169328 skos:altLabel "
Falcidia, E.; Parano, E.; Grillo, A.; Pavone, P.; Takabayashi, H.; Trifiletti, RR.; Scollo, P.; Dallapiccola, B.; Grammatico, P.; Novelli, A.; Paladini, D.; Monni, G.; Gulisano, A.; Scassellati, G. (2004)
Fetal cells in maternal blood: a six-fold increase in women who have undergone amniocentesis and carry a fetus with Down syndrome: a multicenter study
in Neuropediatrics
"^^rdf:HTML ; pubblicazioni:autori "Falcidia, E.; Parano, E.; Grillo, A.; Pavone, P.; Takabayashi, H.; Trifiletti, RR.; Scollo, P.; Dallapiccola, B.; Grammatico, P.; Novelli, A.; Paladini, D.; Monni, G.; Gulisano, A.; Scassellati, G."^^xsd:string ; pubblicazioni:paginaInizio "321"^^xsd:string ; pubblicazioni:paginaFine "324"^^xsd:string ; pubblicazioni:numeroVolume "35"^^xsd:string . @prefix ns11: . prodotto:ID169328 pubblicazioni:rivista ns11:ID607195 ; pubblicazioni:numeroFascicolo "6"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "1. CNR, CNR, Inst Neurol Sci, I-95123 Catania, Italy \n2. Human Reprod Med Unit, Catania, Italy \n3. Human Genet Lab, Catania, Italy \n4. Univ Catania, Dept Pediat, Catania, Italy \n5. Kanazawa Med Univ, Div Human Genet, Med Res Inst, Kanazawa, Ishikawa, Japan \n6. UMDNJ, Dept Neurol & Neurosci, Newark, NJ USA \n7. Cannizzaro Hosp, Dept Obstet & Gynecol, Catania, Italy \n8. Univ Roma La Sapienza, Dept Expt Med & Pathol, Rome, Italy \n9. IRCCS, CSS San Giovanni Rotondo, Rome, Italy \n10. CSS Mendel, Rome, Italy \n11. Univ Naples Federico II, Prenatal Diag Unit, Dept Obstet & Gynecol, Naples, Italy \n12. Microcitemic Hosp, Prenatal Diag Unit, Cagliari, Italy \n13. Univ Catania, Dept Obstet & Gynecol, Catania, Italy \n14. San Camillo Forlanini Hosp, Obstet & Gynecol Unit, Rome, Italy"^^xsd:string ; pubblicazioni:titolo "Fetal cells in maternal blood: a six-fold increase in women who have undergone amniocentesis and carry a fetus with Down syndrome: a multicenter study"^^xsd:string ; prodottidellaricerca:abstract "Fetal nucleated red blood cells (FNRBCs) circulate in the maternal blood throughout pregnancy. Even if the frequency of fetal cells in the maternal circulation remains to be ascertained, complications of pregnancy such as fetal cells aneuploidies, preeclampsia, abnormal Doppler of the uterine artery without symptoms of preeclampsia, fetal growth restriction and polyhydramnios are associated with an increased feto-maternal trafficking. Based on these observations, previous studies have suggested that determination of the fetal nucleated red blood cell count (FNRBCC) might be a useful non-invasive screening test, either alone or in combination with existing maternal tests, for the non-invasive assessment of aneuploidies, in particular Down syndrome (DS). In this paper we have evaluated the distribution of FNRBCC in a set of 18 normal pregnancies and 18 pregnancies with a trisomy 21-affected fetus, matching for gestational age, maternal age, and, when possible, fetal gender, in order to quantify the difference in the number of fetal cells between the two populations. Maternal blood was collected from each pregnant woman two to three weeks after amniocentesis after knowing the cytogenetic results. Correlation of FNRBCC with the gestational week and clinical status (affected vs. non affected) by multiple regression analysis provided significant results (p < 0.001). Adjusted values of FNRBCC were 48 +/- 10.2 in controls and 301 +/- 17.01 in DS cases, corresponding to a 6.27fold increase. These retrospective results prompt a prospective evaluation of the use of FNRBCC for screening purposes."@en ; prodottidellaricerca:prodottoDi istituto:CDS081 , modulo:ID2653 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA5731 . @prefix parolechiave: . prodotto:ID169328 parolechiave:insiemeDiParoleChiave . ns11:ID607195 pubblicazioni:rivistaDi prodotto:ID169328 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID169328 .