@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS081 prodottidellaricerca:prodotto prodotto:ID140536 . @prefix rdf: . @prefix retescientifica: . prodotto:ID140536 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1201 . @prefix rdfs: . prodotto:ID140536 rdfs:label "Non-Neuronal Cells of the Nervous System: Function and Dysfunction/Chapter 13: Regulation of Ca2+ stores in glial cells. (Contributo in volume (capitolo o saggio))"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID140536 pubblicazioni:anno "2003-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID140536 skos:altLabel "
Scapagnini G 1, Nelson TJ 2, Alkon DL 2 (2003)
Non-Neuronal Cells of the Nervous System: Function and Dysfunction/Chapter 13: Regulation of Ca2+ stores in glial cells.
Elsevier, Amsterdam, 2003
"^^rdf:HTML ; pubblicazioni:autori "Scapagnini G 1, Nelson TJ 2, Alkon DL 2"^^xsd:string ; pubblicazioni:citta "Amsterdam"^^xsd:string ; pubblicazioni:note "Giovanni Scapagnini - Ricercatore CNR assunto 25/11/03 matricola 09690"^^xsd:string ; pubblicazioni:descrizioneSinteticaDelProdotto "Virtually all cell functions are regulated by changes in the cytosolic free Ca2+ concentration. In astrocytes, calcium signaling is not restricted to single cells, but can cross cell borders via gap junctions, resulting both in intracellular Ca2+ waves,traveling from one glial cell to the next, and in induction of Ca2\u00FE responses in neurons. In mammals, many glial cells contain an elaborate endoplasmic reticulum. Associated with this membrane network are pumps for Ca2+ uptake (the so-called SERCAs), that, as in other cells, are inhibited by thapsigargin and cyclopiazonic acid. The membranous network also contains Ca2\u00FE-binding proteins for Ca2+ storage and channels for Ca2+induced calcium release. These include the ubiquitous IP3 receptors and, in many cells, the ryanodine receptors. The ryanodine receptors are regulated by a variety of accessory proteins and are sensitive to the classical modulators ryanodine and caffeine. In glia,\nhowever, the major mechanism for Ca2+ release from internal stores involves activation of inositol 1,4,5-trisphosphate (IP3)-gated Ca2+ release channels (IP3 receptors). The mitochondria and calcium storage proteins also function as high-capacity storage sites for calcium.\nOther calcium binding proteins play important roles in cell signaling, maintenance of the cytoskeleton, and apoptosis.\n"^^xsd:string ; pubblicazioni:affiliazioni "1 Institute of Neurological Sciences, CNR, 95123 Catania, Italy;\n2 Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, MD 20850, USA."^^xsd:string ; pubblicazioni:titolo "Non-Neuronal Cells of the Nervous System: Function and Dysfunction/Chapter 13: Regulation of Ca2+ stores in glial cells."^^xsd:string ; pubblicazioni:inCollana "Advances In Molecular and Cell Biology, Vol.31"^^xsd:string . @prefix ns9: . prodotto:ID140536 pubblicazioni:editore ns9:ID252 ; prodottidellaricerca:prodottoDi istituto:CDS081 . @prefix parolechiave: . prodotto:ID140536 parolechiave:insiemeDiParoleChiave . ns9:ID252 pubblicazioni:editoreDi prodotto:ID140536 . parolechiave:insiemeDiParoleChiaveDi prodotto:ID140536 .