@prefix pubblicazioni: . @prefix unitaDiPersonaleInterno: . @prefix prodotto: . unitaDiPersonaleInterno:MATRICOLA9323 pubblicazioni:autoreCNRDi prodotto:ID13698 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID13698 . @prefix modulo: . modulo:ID2642 prodottidellaricerca:prodotto prodotto:ID13698 . @prefix rdf: . @prefix retescientifica: . prodotto:ID13698 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID13698 rdfs:label "Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID13698 pubblicazioni:anno "2006-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1016/j.bbmt.2006.05.017"^^xsd:string . @prefix skos: . prodotto:ID13698 skos:altLabel "
Ferrara F. ; Palmieri S. ; Pollio F. ; Lo Pardo C. ; Graziano D. ; Celentano M. ; D'Amico M.R. ; Vicari L. ; Izzo B. ; Pane F. (2006)
Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia
in Biology of blood and marrow transplantation; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
"^^rdf:HTML ; pubblicazioni:autori "Ferrara F. ; Palmieri S. ; Pollio F. ; Lo Pardo C. ; Graziano D. ; Celentano M. ; D'Amico M.R. ; Vicari L. ; Izzo B. ; Pane F."^^xsd:string ; pubblicazioni:paginaInizio "981"^^xsd:string ; pubblicazioni:paginaFine "986"^^xsd:string ; pubblicazioni:numeroVolume "12"^^xsd:string . @prefix ns11: . prodotto:ID13698 pubblicazioni:rivista ns11:ID214285 ; pubblicazioni:numeroFascicolo "9"^^xsd:string ; skos:note "copu"^^xsd:string , "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "Cardarelli Hosp, Div Haematol, Naples, Italy ; Cardarelli Hosp, Stem Cell Transplantat Unit, Naples, Italy ; Cardarelli Hosp, Transfus Med Serv, Naples, Italy ; Cardarelli Hosp, Serv Med Genet, Naples, Italy ; Univ Naples Federico II, CEINGE, Naples, Italy"^^xsd:string ; pubblicazioni:titolo "Presence of FLT3 mutations does not impair stem cell mobilization and feasibility of autologous peripheral blood stem cell transplantation in acute myeloid leukemia"^^xsd:string ; prodottidellaricerca:abstract "Fetal liver tyrosine kinase 3 (FLT3) mutations represent a powerful prognostic indicator in acute myeloid leukemia (AML). Further, interaction between FLT3 and its ligand plays a role in normal hematopoiesis. Accordingly, FLT3 mutations may affect mobilization of peripheral blood stem cells (PBSCs) and feasibility of autologous stem cell transplantation (ASCT) in AML. We analyzed the effect of FLT3 mutations on mobilization of CD34(+) cells and on PBASCT feasibility from 111 patients with AML, with a median age of 58 years and normal karyotype. Overall, 23 patients (21%) had FLT3 mutations. The complete remission rate was 74% and was not influenced by FLT3 mutations (73% for patients with FLT3(-) and 78% for those with FLT3(+); P = .78). The successful mobilization rate was 79% and was comparable for patients with FLT3(-) and with FLT3(+) (P = .42). Median numbers of CD34(+) cells collected were 7.6 x 10(6)/kg and 7.1 x 10(6)/kg for patients with FLT3(-) and those with FLT3(+), respectively (P = .64). Among 73 patients evaluated for mobilization, feasibility of ASCT was 71%, and there was no difference between patients with FLT3(-) (74%) and those with FLT3(+) (61%), P = .43. We conclude that the FLT3 mutations have no influence on mobilization of CD34(+) cells or on feasibility of PBASCT in patients with AML and normal karyotype. (C) 2006 American Society for Blood and Marrow Transplantation."@en . @prefix ns12: . prodotto:ID13698 pubblicazioni:editore ns12:ID11865 ; prodottidellaricerca:prodottoDi istituto:CDS017 , modulo:ID2642 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA9323 . ns11:ID214285 pubblicazioni:rivistaDi prodotto:ID13698 . ns12:ID11865 pubblicazioni:editoreDi prodotto:ID13698 .