@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID2476 pubblicazioni:autoreCNRDi prodotto:ID13694 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID13694 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA8825 pubblicazioni:autoreCNRDi prodotto:ID13694 . @prefix modulo: . modulo:ID2708 prodottidellaricerca:prodotto prodotto:ID13694 . unitaDiPersonaleInterno:MATRICOLA8928 pubblicazioni:autoreCNRDi prodotto:ID13694 . @prefix rdf: . @prefix retescientifica: . prodotto:ID13694 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID13694 rdfs:label "Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease. (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID13694 pubblicazioni:anno "2007-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID13694 skos:altLabel "
VArrone A, PAgani M, Salvatore E, Salmaso D, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappat\u00E0 P, Salvatore M. (2007)
Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease.
in European journal of nuclear medicine and molecular imaging (Print)
"^^rdf:HTML ; pubblicazioni:autori "VArrone A, PAgani M, Salvatore E, Salmaso D, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappat\u00E0 P, Salvatore M."^^xsd:string ; pubblicazioni:paginaInizio "1071"^^xsd:string ; pubblicazioni:paginaFine "1081"^^xsd:string ; pubblicazioni:numeroVolume "34"^^xsd:string . @prefix ns12: . prodotto:ID13694 pubblicazioni:rivista ns12:ID69266 ; pubblicazioni:pagineTotali "11"^^xsd:string ; pubblicazioni:numeroFascicolo "7"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "A. Varrone : V. Sansone : S. Pappat\u00E0 : M. Salvatore\nBiostructure and Bioimaging Institute, National Research Council/\nDepartment of Biomorphological and Functional Sciences,\nUniversity Federico II,\nNapoli, Italy\nM. Pagani : D. Salmaso\nInstitute of Cognitive Sciences and Technologies,\nNational Research Council,\nRome and Padua, Italy\nE. Salvatore : M. Amboni : G. De Michele : A. Filla : P. Barone\nDepartment of Neurological Sciences, University Federico II,\nNapoli, Italy\nF. Nobili\nClinical Neurophysiology,\nDepartment of Endocrinological and Metabolic Sciences,\nUniversity of Genoa,\nGenoa, Italy"^^xsd:string ; pubblicazioni:titolo "Identification by [99mTc]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease."^^xsd:string ; prodottidellaricerca:abstract "Purpose Progressive supranuclear palsy (PSP) is an akinetic-rigid syndrome that can be difficult to differentiate from Parkinson's disease (PD), particularly at an early stage. [99mTc]ethyl cysteinate dimer (ECD) SPECT could represent a widely available tool to assist in the differential diagnosis. In this study we used voxel-based analysis and Computerised Brain Atlas (CBA)-based principal component analysis (PCA) of [99mTc]ECD SPECT data to test whether: (1) specific patterns of rCBF abnormalities can differentiate PSP from controls and PD; (2) networks of dysfunctional brain regions can be found in PSP vs controls and PD.\nMethods Nine PD patients, 16 PSP patients and ten controls were studied with [99mTc]ECD SPECT using a brain-dedicated device (Ceraspect). Voxel-based analysis was performed with statistical parametric mapping. PCA was applied to volume of interest data after spatial normalisation to CBA. Results The voxel-based analysis showed hypoperfusion of the anterior cingulate and medial frontal cortex in PSP compared with controls and PD. In PSP patients the rCBF impairment extended to the pre-supplementary motor area and prefrontal cortex, areas involved in executive function and motor networks. Compared with PSP patients, PD patients showed a mild rCBF decrease in associative visual areas which could be related to the known impairment of visuospatial function. The PCA identified three principal components differentiating PSP patients from controls and/or PD patients that included groups of cortical and subcortical brain regions with relatively decreased (cingulated cortex, prefrontal cortex and caudate) or increased (parietal cortex) rCBF, representing distinct functional networks in PSP.\nConclusion Anterior cingulate hypoperfusion seems to be an early, distinct brain abnormality in PSP as compared with PD."@en ; prodottidellaricerca:prodottoDi istituto:CDS017 , modulo:ID2708 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA8825 , unitaDiPersonaleEsterno:ID2476 , unitaDiPersonaleInterno:MATRICOLA8928 . ns12:ID69266 pubblicazioni:rivistaDi prodotto:ID13694 .