@prefix pubblicazioni: . @prefix unitaDiPersonaleEsterno: . @prefix prodotto: . unitaDiPersonaleEsterno:ID2476 pubblicazioni:autoreCNRDi prodotto:ID13594 . @prefix prodottidellaricerca: . @prefix istituto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID13594 . @prefix unitaDiPersonaleInterno: . unitaDiPersonaleInterno:MATRICOLA6764 pubblicazioni:autoreCNRDi prodotto:ID13594 . @prefix modulo: . modulo:ID2708 prodottidellaricerca:prodotto prodotto:ID13594 . @prefix rdf: . @prefix retescientifica: . prodotto:ID13594 rdf:type retescientifica:ProdottoDellaRicerca , prodotto:TIPO1101 . @prefix rdfs: . prodotto:ID13594 rdfs:label "Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (Articolo in rivista)"@en . @prefix xsd: . prodotto:ID13594 pubblicazioni:anno "2005-01-01T00:00:00+01:00"^^xsd:gYear ; pubblicazioni:doi "10.1210/jc.2004-2135"^^xsd:string . @prefix skos: . prodotto:ID13594 skos:altLabel "
Savastano, S; Pivonello, R; Acampa, W; Salvatore, M; Lombardi, G; Colao, A; Fenzi, G (2005)
Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy
in The Journal of clinical endocrinology and metabolism
"^^rdf:HTML ; pubblicazioni:autori "Savastano, S; Pivonello, R; Acampa, W; Salvatore, M; Lombardi, G; Colao, A; Fenzi, G"^^xsd:string ; pubblicazioni:paginaInizio "2440"^^xsd:string ; pubblicazioni:paginaFine "2444"^^xsd:string ; pubblicazioni:numeroVolume "90"^^xsd:string . @prefix ns12: . prodotto:ID13594 pubblicazioni:rivista ns12:ID294077 ; pubblicazioni:pagineTotali "5"^^xsd:string ; pubblicazioni:numeroFascicolo "4"^^xsd:string ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:affiliazioni "University of Naples Federico II; University of Naples Federico II"^^xsd:string ; pubblicazioni:titolo "Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy"^^xsd:string ; prodottidellaricerca:abstract "Here we describe the case of a 60-yr-old nonsmoking woman with a history of Graves' disease associated with papillary thyroid carcinoma. After tumor removal, during the diagnostic follow-up for thyroid cancer, there was evidence of severe Graves' ophthalmopathy ( GO) successfully treated with iv glucocorticoids. After this treatment, GO entered inactive status. The patient was then reevaluated for thyroid cancer with human recombinant TSH (rTSH). Orbital [In-111-diethylenetriaminepentacetic acid ( DTPA)-D-phe(1)] octreotide scan was also performed, and results were negative. Shortly after rTSH administration, a moderate and transient pain behind the eye globes at rest and during eye movement was reported, with an increase in the activity score but without further GO progression. Twenty-four hours after rTSH administration, the patient was submitted to a second [In-111-DTPA-D-phe(1)]octreotide scan, revealing significant orbital uptake, likely related to rapid accumulation of activated lymphocytes with inflammatory cytokines or fibroblasts expressing somatostatin receptors in the orbital tissue or interstitial edema due to the inflammation process. At last follow-up performed after 1 yr, there was no evidence of active thyroid cancer or changes in GO severity and/or activity, and orbital [In-111-DTPA-D-phe(1)] octreotide uptake was negative. This case further supports the involvement of TSH receptor in the pathogenesis of GO. It also confirms the usefulness of orbital [In-111-DTPA-D-phe(1)] octreotide scan to evaluate GO activity."@en ; prodottidellaricerca:prodottoDi istituto:CDS017 , modulo:ID2708 ; pubblicazioni:autoreCNR unitaDiPersonaleInterno:MATRICOLA6764 , unitaDiPersonaleEsterno:ID2476 . ns12:ID294077 pubblicazioni:rivistaDi prodotto:ID13594 .