@prefix prodottidellaricerca: . @prefix istituto: . @prefix prodotto: . istituto:CDS017 prodottidellaricerca:prodotto prodotto:ID13386 . @prefix rdf: . prodotto:ID13386 rdf:type prodotto:TIPO1101 . @prefix retescientifica: . prodotto:ID13386 rdf:type retescientifica:ProdottoDellaRicerca . @prefix rdfs: . prodotto:ID13386 rdfs:label "Voxel-based comparison of rcbf SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical network (Articolo in rivista)"@en . @prefix xsd: . @prefix pubblicazioni: . prodotto:ID13386 pubblicazioni:anno "2002-01-01T00:00:00+01:00"^^xsd:gYear . @prefix skos: . prodotto:ID13386 skos:altLabel "
Varrone A., Pappata S., Caraco C., Soricelli A., Milan G., Quarantelli M., Alfano B., Postiglione A., Salvatore M. (2002)
Voxel-based comparison of rcbf SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical network
in European journal of nuclear medicine
"^^rdf:HTML ; pubblicazioni:autori "Varrone A., Pappata S., Caraco C., Soricelli A., Milan G., Quarantelli M., Alfano B., Postiglione A., Salvatore M."^^xsd:string ; pubblicazioni:paginaInizio "1447"^^xsd:string ; pubblicazioni:paginaFine "1454"^^xsd:string ; pubblicazioni:numeroVolume "29(11"^^xsd:string . @prefix ns9: . prodotto:ID13386 pubblicazioni:rivista ns9:ID347484 ; skos:note "ISI Web of Science (WOS)"^^xsd:string ; pubblicazioni:titolo "Voxel-based comparison of rcbf SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical network"^^xsd:string ; prodottidellaricerca:abstract "Characteristic patterns of regional cerebral blood flow (rCBF) reduction, \nas detected by technetium-99m hexamethylpropylene amine oxime ((99m)Tc-\nHMPAO) single-photon emission tomography (SPET), may help clinicians in \ndifferentiating patients with frontotemporal dementia (FTD) from those \nwith Alzheimer's disease (AD). However, in some cases these patients may \nshare common rCBF abnormalities and the visual analysis and/or the region \nof interest (ROI) approach may not sensitively detect more localised focal \nchanges that could be more specific for each pathology. Recently, \nautomated voxel-by-voxel statistical analysis of perfusion brain maps has \nbeen applied to SPET images. This method has the advantage of including \nthe rCBF information for the whole brain for statistical analysis without \nany a priori hypothesis regarding the regions possibly involved. This \ncould result in a better characterisation of rCBF differences in brain \nregions while also reducing the operator's subjectivity and the time \nrequired for data analysis. The purpose of this study was to apply such a \ntechnique to highlight the specific brain areas showing a relative \nfunctional involvement in FTD and AD. Thus, we compared the relative rCBF \npatterns obtained in eight FTD patients with those obtained in 21 AD \npatients using (99m)Tc-HMPAO SPET and statistical parametric mapping \n(SPM). When FTD patients were compared with AD patients, relatively lower \nrCBF was observed in right medial frontal cortex (BA 8, 9, 10), right \nanterior cingulate cortex (BA 32), right temporal cortex (BA 21/22), right \norbitofrontal cortex (BA 11) and ventrolateral prefrontal cortex (BA 47); \nin BA 47 the reduction was evident bilaterally but was more marked on the \nright side. On the other hand, when AD patients were compared with FTD \npatients, a significant relative rCBF decrease was found in the bilateral \nsuperior parietal cortex (BA 7); this decrease was more extensive on the \nleft side, where it also included the inferior parietal (BA 40), superior \noccipital (BA 19) and temporo-occipital regions (BA 39, 19). The results \nof this study confirm the preferential involvement of the frontotemporal \nregions in FTD patients and of the temporoparietal regions in AD patients. \nFurthermore, they highlight the networks that are more specifically \nimpaired in these disorders and that could be implicated in the emotional-\nbehavioural and cognitive disturbances that characterise FTD and AD \nrespectively." ; prodottidellaricerca:prodottoDi istituto:CDS017 . ns9:ID347484 pubblicazioni:rivistaDi prodotto:ID13386 .